The aim of this paper is to study the relativity between oxidative stress and cervical squamous cell carcinoma (CSCC) . Cervical cancer and healthy crowd cervical tissue were collected, and their content of Peroxiredoxin 6 (PRDX6) was measured and compared with Western Blot. PRDX6 was highly expressed in human CSCC tissue compared with healthy control, indicating that PRDX6 is a sensitive oxida...

The development of cervical cancer requires genetic and epigenetic factors which result in the persistence of a malignant phenotype. Cervical cancer exhibits also some unique differences from other solid tumors. Normal cervical stratified epithelia have characteristics of hypoxic tissue with over-expression of HIF-1 (hypoxia-inducible factor-1) tr...

Current morphology-based cervical cancer screening is associated with significant false-positive and false-negative results. Tumor suppressor gene hypermethylation is frequently present in cervical cancer. It is unknown whether a cervical scraping reflects the methylation status of the underlying epithelium, and it is therefore unclear whether quantitative hypermethylation specific PCR (QMSP) o...

BACKGROUND AND OBJECTIVE Fluorescence spectroscopy has been shown to provide information useful in the detection of cervical dysplasia. The goal of this study was to determine if substances found on the cervix such as acetic acid, mucus, and vaginal medications can influence the fluorescence in the spectral region useful for discriminating normal cervical tissue from abnormal tissue. STUDY DE...

Although rare, synovial sarcoma is the most common malignant non-rhabdomyosarcomatous soft tissue sarcoma in children and adolescents. Synovial sarcoma typically involves the soft tissues of the extremities, especially near large joints, but it can occur anywhere in the body in locations far from joint spaces. Although this tumor typically affects adults in their fourth decade of life, nearly h...

a 35-year-old man was admitted because of a 2-year history of nasal obstrction, a nasopharyngeal mass, malaise, and massive cervical lymphadenopathy. nasal symptoms and nasopharygeal mass were due to rhinoscleroma that was confirmed by an incisional biopsy and culture. the patient underwent cervical lymph node biopsy and culture. the patient underwent cervical lymph node biopsy that revealed th...

background: cervical pregnancy is rare and dangerous form of ectopic pregnancy which can be treated surgically or conservatively. methotrexate is reasonable conservative option with high efficiency and acceptable level of side effects. aim of this paper is to present possible treatment option in case of methotrexate failure, still keeping the postulates of minimal invasive surgery. case:  we de...

One hundred and six patients were studied whose cervical smears showed only non-specific inflammatory changes. Screening for genital pathogens yielded only a few positive cases. Histological examination of biopsy specimens taken by colposcopically directed tissue sampling showed cervical intraepithelial neoplasia in 13 of the women (12.3%). Deoxyribonucleic acid (DNA) hybridisation techniques w...

OBJECTIVES The aims of this study were to investigate the functions of GAS5 as a tumor suppressor in cervical cancer and explore the mechanism. METHODS The expression of GAS5 and microRNA 21 (miR-21) was detected in primary cervical cancer tissue specimens, as well as in cervical cancer cell lines. We identified the interaction of GAS5 and miR-21 by quantitative polymerase chain reaction, Wes...

High vascularity correlates with poor clinical outcome in cancer of the uterine cervix. We investigated whether human cervical cancer cell (HeLa) metabolites influenced endothelial cell proliferation through the serine protease, tissue kallikrein. The angiogenic potential of tissue kallikrein is proposed due to its proteolytic, mitogenic and invasive properties. Under pre-defined conditions, we...