Programmed cell death 4 (PDCD4) is a tumor suppressor, and it inhibits tumor progression and metastasis. Even though down-regulation of PDCD4 has been implicated with many different types of human cancers, its roles in the progression of cervical cancer remain unexplored. Here, we have systematically examined the expression pattern of PDCD4 in cervical tissues. 15 cervical normal tissues, 14 ce...

The binding characteristics of monoclonal antibodies produced against a variety of human tumor cells were studied on cervical carcinoma cell lines and on exfoliated cells of cervical smears. The latter included normal epithelial cells, cells derived from cervical intraepithelial neoplasia, and cells from squamous cell carcinoma. Monoclonal antibodies that bound in immunoperoxidase assays to eth...

myeloid sarcoma is a rare extramedullary tumor of immature myeloid cells. it has been very rarely reported as lateral cervical mass in english literature. myeloid sarcoma has also been reported with marked eosinophilia. here we present a 17 year old boy with lateral cervical mass and persistent eosinophilia. the mass was isointense in mri and homogenously enhanced after contrast injection which...

papillary microcarcinoma of thyroid (pmc) as a variant of papillary carcinoma less than 1 cm in size is a new clinicopathological entity, with high incidence and good prognosis. there are many differences between pmc and clinically apparent papillary thyroid carcinoma. also, there are some pmc case reports with unusual metastasis and aggressive courses. prognostic factors are age, size and morp...

Introduction: Cervical cancer is the third most common tumor among women. Surgery, radiotherapy, and chemotherapy are common treatments, however high stage tumors have frequently poor prognosis. Nowadays, the epigenetic reversion introduced as an efficient strategy of treatment of cervical cancer. In the process, inhibitors of DNA methyltransferase (DNMT) induce re-expression of tumor suppresso...

PURPOSE Invasive and recurrent cervical cancer accounts for major mortality among women. The activity of biomarkers in cervical cancer varies with different pathological stages. The purpose of the present study was to evaluate the expression of 2 biomarkers in cervical cancer and their possible contribution to novel therapeutic strategies. METHODS In this study, we assessed the expression of ...

BACKGROUND Cervical nodal status is one of prognostic factors in head and neck squamous cell carcinoma (HNSCC). The objective of this study was to identify prognostic factors of cervical node status including site and size of primary tumors, presence of lymphovascular invasion, and size of cervical node for appropriate further treatment in HNSCC. METHODS A 5-year retrospective review of patie...

Surgery and radiation are the current standard treatments for cervical cancer. However, there is no effective therapy for metastatic or recurrent cases, necessitating the identification of therapeutic targets. In order to create preclinical models for screening potential therapeutic targets, we established 14 patient-derived xenograft (PDX) models of cervical cancers using subrenal implantation...

High-risk human papillomavirus (HR-HPV) infections are among the most important factors for cervical carcinogenesis. However, whether patients infected with HR-HPV eventually develop a malignant tumor, largely depends on epithelial-mesenchymal transition (EMT), which plays an extraordinary role in the process of carcinogenesis and metastasis. Therefore, we evaluated the protein levels of EMT-re...

Although microRNAs (miRNAs or miRs) are able to function as oncogenes or tumor suppressors, the role of miR-326 in regulating human cervical cancer cells remains unclear. In the present study, the expression of miR-326 was identified to be downregulated in cervical cancer cell lines and primary tumor samples, and the overexpression of miR-326 decreased cell proliferation, migration and invasion...