γ-Valerolactone as a renewable, polar aprotic solvent was evaluated in the selective hydrogenation of carbon-carbon double bond chalcones from both catalytic and mechanistic aspects. By using triphenylphosphine-modified cationic rhodium catalyst systems reasonably high activities (TOFinitial∼1200 h−1) were achieved (E)-chalcone (CHL), common model substrate for α,β-unsaturated ketones, to dihyd...

Background: Streptococcus mutans is one of the most important microorganisms in tooth decay. Sortase A (SrtA) S. responsible for attachment bacteria to host cell and biofilm formation. Therefore, it seems necessary investigate inhibitors this enzyme prevent dental caries. Chalcones are always interest medical community due their wide range biological activities. Many studies have reported that ...

New cDNA sequences for chalcone synthase (CHS), a key enzyme in the flavonoid biosynthesis, were obtained from the Japanese and common morning glories; they are more closely related to other CHS sequences than the six previously described CHS genes from the same plants. The newly isolated CHS-D gene is abundantly expressed in the pigmented flower buds, while its expression is drastically reduce...

A simple and rapid method was developed using cyclic, differential pulse and square wave voltammetric techniques for the determination of trace-level chalcone at a glassy carbon electrode. Chalcone could produce two anodic peaks at about 0.514 V and 1.478 V and a cathodic peak at about −0.689 V. The differential pulse voltammerty presents a good linear response as compared to square wave voltam...

Substantial progress has been made in elucidating the biosynthesis of plant phenolics, one major class of which is the flavonoids. Flavonoids are involyed in many plant functions such as UV protection, defense against pathogen attack, legume nodulation, pigmentation and pollen viability (Firmin et al. 1986, Hahlbrock and Scheel 1989, Dixon and Harrison 1990). Due to such important functions, st...

In the present manuscript, a novel fluorescent chalcone derivative is synthesized and its photophysical properties are fully characterized. The designed fluorophore is applied as a probe to study protein-dye interactions with bovine serum albumin. Circular dichroism gave interesting results on the thermodynamics of the interaction. NMR spectroscopy, especially relaxation measurements, revealed ...

The regioselective and enantioselective Michael addition between azlactones and o-hydroxy chalcone derivatives is reported. Enantiomerically enriched N,O-aminals with two continuous stereogenic centers are exclusively obtained in moderate to good yields with excellent diastereoselectivities and good to excellent enantioselectivities. The experimental results show that an o-hydroxy group on the ...

We have previously cloned a chalcone synthase (PcCHS1) from Polygonum cuspidatum and biochemically identified its enzymatic dynamic properties. Here, we found that the outer sphere residues, Q82 and R105, could affect the catalytic activity and product profile of PcCHS1. Both Q82P and R105Q mutations of PcCHS1 could also change the pH dependence activity as well as the product profile of PcCHS1...

In the title compound, C(25)H(18)ClNO, the conformation about the C=C double bond is E. Significant twists are evident in the mol-ecule, with the benzene ring forming a dihedral angle of 53.92 (11)° with the quinolinyl residue. Further, the chalcone residue is approximately perpendicular to the quinolinyl residue [C(q)-C(q)-C(c)-O(c) torsion angle = -104.5 (3)°, where q = quinolinyl and c = cha...

A series of chalcone-based macrocyclic ethers have been synthesized. These macrocyclic ethers contain polyether as well as extended conjugation to the benzene ring to function as fluorescent sensor for cations. The modeling studies show that the chalcone part of the receptors remains partially out of plane from the polyether part and the keto moiety of the receptors always directed outwardly in...