Corneal clarity is maintained by its endothelium, which functions abnormally in the endothelial dystrophies, leading to corneal opacification. This group of conditions includes Fuchs' endothelial dystrophy of the cornea (FECD), one of the commonest indications for corneal transplantation performed in developed countries, posterior polymorphous dystrophy (PPCD) and the congenital hereditary endo...

Bacteria switch the direction their flagella rotate to control movement. FliM, along with FliN and FliG, compose a complex in the motor that, upon binding phosphorylated CheY, reverses the sense of flagellar rotation. The 2.0-A resolution structure of the FliM middle domain (FliM(M)) from Thermotoga maritima reveals a pseudo-2-fold symmetric topology similar to the CheY phosphatases CheC and Ch...

Members of the cell division cycle 2 (CDC2) family of kinases play a pivotal role in the regulation of the eukaryotic cell cycle. In this communication, we report the isolation of a cDNA that encodes a CDC2-related human protein kinase temporarily designated PITALRE for the characteristic Pro-Ile-Thr-Ala-Leu-Arg-Glu motif. Its deduced amino acid sequence is 47% identical to that of the human ch...

We have isolated and characterised a novel human protein kinase, Cdc2-related kinase with an arginine/serine-rich (RS) domain (CrkRS), that is most closely related to the cyclin-dependent kinase (CDK) family. CrkRS is a 1490 amino acid protein, the largest CDK-related kinase so far isolated. The protein kinase domain of CrkRS is 89% identical to the 46 kDa CHED protein kinase, but outside the k...

Bacillus subtilis has a more complex mechanism of chemotaxis than does the paradigm organism, Escherichia coli. In order to understand better the role of the novel chemotaxis proteins--CheC, CheD and CheV--mutants in which increasing numbers of the corresponding genes had been deleted were studied as tethered cells and their biases and sometimes durations of counterclockwise (CCW) and clockwise...

This pa.per investigates the asymptotic behavior of a single server queue with truncated heavy-tailed arrival sequences. 14'-e have discovered and explicitly asymptotically cha.ra.cterized a unique asymptotic behavior of t,he queue length distribution. Informally, this distribution on t,he log scale resembles a stair-wave function t h t lias steep drops a t specific buffer sizes. This has impor...

Quality maritime graduates attract better employment opportunities. This descriptive survey study aimed at determining the status of Bachelor Science in Marine Engineering (BSMarE) University Antique from 2013 - 2016 as basis for proposing an action plan. The research method was used this study. A Commission on Higher Education (CHED) graduate tracer adopted and modified to ensure appropriatene...

tire industry in is ecountring  an internal  competitive  market, so they need to incease their efforts in international markets. it seems that these  efforts should  be directed  by the knowledge of global marketing theories. in this research the application level of marketing theories in tire industry is measured,and by offering a model  with three categories of marketing elements. the optimu...

Commission on Higher Education Memorandum Order Number 20 s-2013 specified the General (GE) outcomes which all Institutions in country should aim to realize through implementation of Outcomes-Based (OBE). This research ascertained degree developed by CHED for new GE were realized course Mathematics Modern World (MATWRLD), and formatively evaluate teaching/learning course. It employed descriptiv...

Purpose To establish conditionally immortal mouse corneal endothelial cell lines with genetically matched Slc4a11+/+ and Slc4a11-/- mice as a model for investigating pathology and therapies for SLC4A11 associated congenital hereditary endothelial dystrophy (CHED) and Fuchs' endothelial corneal dystrophy. Methods We intercrossed H-2Kb-tsA58 mice (Immortomouse) expressing an IFN-γ dependent and...