There are presently three approaches to radiolabeling antibodies: direct radiolabeling; radiolabeling of a chelating agent conjugated to an antibody; and radiolabeling of a chelating agent before conjugation to an antibody. Using either the direct radiolabeling or radiolabeling of a chelating agent conjugated to an antibody has not led to a radiochemically pure ""Tc-labeled protein. High radioc...

The role of zinc in the catalytic action of yeast alcohol dehydrogenase has been studied through the kinetics of the inhibition of activity by chelating agents (I), particularly l,lO-phenanthroline (2-4). In aqueous solution the complexes of 1, lo-phenanthroline with Zn++ ions exhibit characteristic absorption spectra, as do the complexes of this agent with the zinc atoms of yeast alcohol dehyd...

Knowledge of lead's capacity to disrupt the prooxidant/antioxidant balance within mammalian tissues suggests that definitive therapy for chronic lead poisoning should encompass both chelating and antioxidant actions. The dithiol meso-2,3-Dimercaptosuccinic Acid (DMSA) is the first orally administered metal chelating agent to receive U.S. Food and Drug Administration (FDA) approval for the treat...

Fatigue-induced damage plays an important role in bone remodelling and in the formation of stress and fragility fractures. Recently, a technique has been developed (Lee, T.C. et al., Sequential labelling of microdamage in bone using chelating agents. Journal of Orthopedic Research, 18 (2000) 322-325) which allows microcrack growth in trabecular bone to be monitored by the application of a serie...

Chelating agents’ application for EOR and well stimulation is fast growing nowadays. However, reagents of this class have some drawbacks, with high values interfacial tension (IFT) being among them. IFT may be lowered the addition surfactants; however, simultaneous chelating agents surfactants has not yet been widely studied. This paper focuses on experimental theoretical investigation interact...

CONTEXT Lead toxicity is an ongoing concern worldwide, and children, the most vulnerable to the long-lasting effects of lead exposure, are in urgent need of a safe and effective heavy metal chelating agent to overcome the heavy metals and lead exposure challenges they face day to day. OBJECTIVE This clinical study was performed to determine if the oral administration of modified citrus pectin...

Solid phase extraction (SPE) techniques have been widely used for the pre-concentration and separation of trace metal ions in aqueous systems prior to their determination. Among the techniques available, the dithiocarbamate solid-phase extraction method is very selective because dithiocarbamate reagents do not react with many metals (alkali, earth alkali and some other metals such as Al and Cr)...