Objective(s):Global cerebral ischemia-reperfusion injury causes loss of pyramidal cells in CA1 region of hippocampus. In this study, we investigated the possible neuroprotective effects of the ethanol extract of Cyperus rotundus (EECR) on a model of global transient ischemia in rat, by evaluating the pathophysiology of the hippocampal tissue and spatial memory. Materials and Methods: Treatment ...

the relationship between qt dispersion and myocardial ischemia is still controversial. therefore, we aimed to investigate the relationship between qtd and the severity and extent of myocardial ischemia. in this cross-sectional study, 141 patients having symptoms of cad who referred to our medical center during 2009-2010, and were examined with myocardial isotope scan and ecg, were enrolled. bas...

Sodium 4-phenylbutyrate (4-PBA) is a low molecular weight fatty acid that has been used for treatment of urea cycle disorders in children, sickle cell disease, and thalassemia. It has been demonstrated recently that 4-PBA can act as a chemical chaperone by reducing the load of mutant or mislocated proteins retained in the endoplasmic reticulum (ER) under conditions associated with cystic fibros...

One of the main directions in development modern electroanalytical chemistry is new effective methods for research and analysis biological objects, particularly, human blood serum. The creation electrochemical sensors a promising approach, which has determined several applied voltammetry field chemical analytical control. In this work, dynamics parameters total antioxidant activity serum patien...

Effects of Alpha Adrenergic Blockade on Autoregulation and Chemical Vasomotor Control of CBF in Stroke • Autoregulation and chemical vasomotor control of cerebral blood flow (CBF) were quantitatively tested in 19 patients with various types and sites of cerebral ischemia and infarction. The effect of alpha adrenergic blockade of cerebral vessels by phenoxybenzamine (PBZ) also was evaluated in m...

Corneal neovascularization is a serious condition that may arise secondary to chemical burns, ischemia, infection, trauma, and inflammation and represents a major cause of blindness. This study investigated the efficacy of topical application of infliximab [tumor necrosis factor-a (TNF-a) monoclonal antibody] in the treatment of corneal neovascularization in the rabbit model.

Objective(s):Biochemical markers are important for the timely diagnosis and follow-up of ischemic events. Most of the markers have been previously studied in the context of cardiac ischemia. However, research on markers of non-cardiac events has been insufficient. Therefore, we investigated the relationship between troponin and myoglobin which are commonly used markers of cardiac ischemia, in n...

abstract  introduction: ischemic heart diseases (ihd) is the major cause of mortality and morbidity worldwide. diabetes mellitus (dm) is known as one of the main risk factors of ihd. silent ischemia is seen in diabetic patients more that in others. identification of these cases is of great value in clinical practice. in this study, ecg changes and their relationship with clinical symptoms of is...