The concept of wireless sensor networks conjures up images of a world of ubiquitous sensing, but it requires a massive increase in the number of sensors available. Although there has been considerable activity in transducer-based 'sensor nets', there have been virtually no corresponding deployments of chemical- or biological-sensing networks - considerable advances in materials science are need...

A smart and reversible chemo-mechanical switch was developed by synthesis of a thermally responsive block copolymer brush poly(N-isopropylacrylamide-co-hexafluoroisopropyl acrylate) (P(NIPAAm-co-HFIPA)) on a capillary plate. With the temperature changing around lower critical solution temperature (LCST), the designed chemo-mechanical switch exhibited excellent "ON-OFF" behavior for water transp...

We report a prototype approach to formulate gold nanoparticle-based X-ray absorbing agents through surface-engineering of a cisplatin pharmacophore with modified polyacrylate. The resulting agents exhibit both chemo-therapeutic potency to cancer cells and Auger-mediated secondary electron emission, showing great potential to improve the therapeutic efficacy of chemo-radiation.

Abstract A chemo-thermo-mechanical problem is solved using a peridynamic approach to investigate crack propagation in non-reinforced concrete at early-age. In the present study, temperature evolution and variation of hydration degree conjunction with mechanical behaviour cement-based materials are examined. Firstly, new model introduced solve fully coupled chemo-thermal problems by satisfying t...

Convolutional neural networks (CNNs), in a few decades, have outperformed the existing state of art methods classification context. However, way they were formalised, CNNs are bound to operate on euclidean spaces. Indeed, convolution is signal operation that defined This has restricted deep learning main use euclidean-defined data such as sound or image. And yet, numerous computer application f...

PURPOSE Formalin-fixed, paraffin-embedded tumor samples from CALGB 80203 were analyzed for expression of EGFR axis-related genes to identify prognostic or predictive biomarkers for cetuximab treatment. PATIENTS AND METHODS Patients (238 total) with first-line metastatic colorectal cancer (mCRC) were randomized to FOLFOX or FOLFIRI chemotherapy ± cetuximab. qRT-PCR analyses were conducted on t...

Drug resistance is the major reason for therapeutic failure during cancer treatment. Chemo-photodynamic combination therapy has potential to improve the treatment efficiency in drug-resistant cancers, but is limited by the incompatible physical properties of the photosensitizer with a chemo-drug and poor accumulation of both drugs into the inner areas of the tumor. Herein, a novel drug delivery...

BACKGROUND Cancer-related fatigue (CRF) affects a majority of patients (pts) with symptoms lasting up to several years after finishing therapy. These symptoms lead to decreased health related quality of life. Fatigue during treatment for colorectal cancer is common, but poorly understood and can affect compliance with post-surgical cancer therapy. We examined the fatigue levels during first-lin...

PURPOSE In elderly patients with esophageal cancer (EC), esophagectomy is associated with an increased mortality, and therefore these patients are often treated with definite (chemo)radiation. The purpose of this study was to assess the toxicity and efficiency of definite radio(chemo)therapy in patients >75 years compared with definite radio(chemo)therapy in patients <75 years. METHODS 32 pat...

Chemotherapy is associated with cognitive impairment in a subgroup of breast cancer survivors, but the neural circuitry underlying this side effect is largely unknown. Moreover, long-term impairment has not been studied well. In the present study, functional magnetic resonance imaging (fMRI) and neuropsychological testing were performed in breast cancer survivors almost 10 years after high-dose...