STUDY OBJECTIVES To examine a national data set of all childhood cancers for evidence of space-time interactions within three distinct sets of dates and places (at birth, at diagnosis, and at death), to show whether the patterns found for these events represent separate phenomena or statistically interdependent processes, and to see whether the childhood leukaemias and the childhood solid cance...

Arsenic in drinking water is an established cause of lung, bladder, and skin cancers in adults and may also cause adult kidney and liver cancers. Some evidence for these effects originated from region II of Chile, which had a period of elevated arsenic levels in drinking water, in particular from 1958 to 1970. This unique exposure scenario provides a rare opportunity to investigate the effects ...

Human immunodeficiency virus (HIV) related cancers in children are not as common and as well described as in adults. An HIV epidemic has been prevalent in Zambia since 1983-1984. To study the effect of the epidemic on the epidemiology of cancers in children a retrospective study was undertaken at the University Teaching Hospital (UTH), Lusaka, Zambia. All the histopathological records from 1980...

background: gastric and colorectal adenocarcinoma are the second and the fifth most common cancers in iran, respectively. expression of cytokeratin 7 (ck7) is established in most malignancies including gastric and colorectal adenocarcinoma. demonstration of ck7 could be related to prognostic factors and help to the better management of the patients. the objective of our study was to evaluate th...

OBJECTIVE Childhood cancer is a leading cause of child deaths in affluent countries, but little is known about its aetiology. Psychological stress has been suggested to be associated with cancer in adults; whether this is also seen in childhood cancer is largely unknown. We investigated the association between bereavement as an indicator of severe childhood stress exposure and childhood cancer,...

The insulin-like growth factor (IGF) family consists of ligands (IGF-I, IGF-II, insulin), several receptors (including IGF-1R), and six binding proteins (IGFBP-1 through IGFBP-6). Members of this family regulate key cellular activities and they also play an important role in the development and progression of both adult and childhood cancers. Binding of a ligand to the receptor leads to its act...

Brain and central nervous system (CNS) tumours (malignant and non-malignant) are the second most common group of cancers in children, accounting for a quarter of all childhood cancers. In the UK, brain tumours occur in about 5 per 100,000 of children between the ages of 0-9 years. The largest subgroup is astrocytoma (43% of all brain and CNS tumours in children). Astrocytomas are diagnosed thro...

Brain and central nervous system (CNS) tumours (malignant and non-malignant) are the second most common group of cancers in children, accounting for a quarter of all childhood cancers. In the UK, brain tumours occur in about 5 per 100,000 of children between the ages of 0-9 years. The largest subgroup is astrocytoma (43% of all brain and CNS tumours in children). Astrocytomas are diagnosed thro...

Brain and central nervous system (CNS) tumours (malignant and non-malignant) are the second most common group of cancers in children, accounting for a quarter of all childhood cancers. In the UK, brain tumours occur in about 5 per 100,000 of children between the ages of 0-9 years. The largest subgroup is astrocytoma (43% of all brain and CNS tumours in children). Astrocytomas are diagnosed thro...

objectives this study aimed at reviewing the current literature on the diagnosis, staging, and different treatment strategies for wilms’ tumor with either ureteral or intravascular extension. evidence acquisition in this article, we reviewed the current literature about staging, diagnosis, and management strategies for wt, through a randomized clinical trial, which focused on this matter. the m...