Intracisternally administered cholecystokinin produced long lasting hypothermia in mice, and the hypothermic effect was significantly antagonized by benzodiazepines like chlordiazepoxide and diazepam and by a benzodiazepine antagonist, Ro 15-1788, that were administered intraperitoneally. Proglumide, a cholecystokinin antagonist, failed to prevent the hypothermia induced by cholecystokinin at a...

Objective(s) Psychotropic medications produce their effects, in part, through increasing neurotrophin levels in the brain. Since studies concerning nerve growth factor (NGF) analysis have been limited in scope, in the current experiments we investigated the effects of diverse psychotropic agents on NGF protein levels in various brain regions of rat. Materials and Methods Male Wistar rats rec...

Naturally occurring polyphenols are potent antioxidants. Some of these compounds are also ligands for the GABA(A) receptor benzodiazepine site. This feature endows them with sedative properties. Here, the anxiolytic activity of the green tea polyphenol (-)-epigallocatechin gallate (EGCG) was investigated after acute administration in mice, using behavioral tests (elevated plus-maze and passive ...

The alcohol withdrawal syndrome is charac terised by symptoms such as anxiety, insomnia, anorexia, nausea, tremor, sweating and distur bances in coordination. These symptoms tend to occur within 6 to 12 hours of alcohol-dependent patients stopping or reducing their alcohol in take. Less frequently, convulsions, hallucinosis and delirium tremens can occur. Delirium tremens (disturbed orientation...

This article discusses the contribution of Marc Richelle to study temporal regulation behaviour in animals. was a pioneer behavioural pharmacology Europe 1960s, and some his early pharmacological experiments, particular those involving chlordiazepoxide, are discussed. frequently tested drug effects on performance fixed-interval (FI) differential reinforcement low rate (DRL) schedules. Much late...