Obesity predisposes to vitamin D deficiency (VDD) and glucose abnormalities. It is currently debated if vitamin D administration may improve glucose homeostasis by interacting with modulators of insulin sensitivity, such as adiponectin and its oligomers. In a 4-week inpatient study on a metabolic rehabilitation program, consisting of individualized caloric restriction and aerobic physical exerc...

OBJECTIVE Investigate whether cholecalciferol supplementation leads to weight loss in overweight and obese adults. DESIGN Randomized double blind clinical trial with 20,000 IU cholecalciferol twice a week, or 20,000 IU once a week plus placebo, or placebo twice a week, for 12 months. All subjects were given 500 mg calcium supplementation. METHODS Four hundred and forty five healthy, overwei...

BACKGROUND Osteoporosis and bone fractures seem to be higher in HIV-infected Patients compared to the general populations. Moreover, bone turnover markers are increased in patients on antiretroviral therapy and vitamin D deficiency is prevalent in HIV-infected patients. However, the influence of per oral cholecalciferol on bone metabolism in HIV infected patients is not well understood. METHO...

BACKGROUND Low vitamin D levels can be associated with albuminuria, and vitamin D analogs are effective anti-proteinuric agents. The aim of this study was to investigate differences in vitamin D levels between those with micro- and those with macroalbuminuria, and to determine whether low dose cholecalciferol increases vitamin D levels and ameliorates albuminuria. METHODS Two studies were per...

the present work compared the clinical efficacy of ropically applied vitamin d3 (cholecalciferol), i a, 25 dihydroxy vitamin d3 (cakitriol) with calcipotriol (dovonex} in the treatment of plaque psoriasis. a randomized, double - blind, left - right, vehicle controlled study to assess the therapeutic efficacy and safety of mice daily application of 1 pg/g and 5 fj.g1g chalecakiferol. 1 pglg calc...

CONTEXT Current approaches to antenatal vitamin D supplementation do not account for interindividual differences in 25-hydroxyvitamin D (25(OH)D) response. OBJECTIVE We assessed which maternal and environmental characteristics were associated with 25(OH)D after supplementation with cholecalciferol. DESIGN Within-randomization-group analysis of participants in the Maternal Vitamin D Osteopor...

Three side-chain analogues of cholecalciferol (vitamin D3) modified at C-25, namely 25-fluorocholecalciferol, 24-dehydrocholecalciferol and 25-dehydrocholecalciferol, conceived as potential inhibitors of the cholecalciferol 25-hydroxylase have been prepared and tested in the rat. These compounds markedly diminish conversion in vivo of cholecalciferol into 25-hydroxycholecalciferol, but are not ...

OBJECTIVE To describe a patient with multiple sclerosis (MS) who developed severe hypercalcemia, attributed to the additive effect of 5500 IU of cholecalciferol and 2020 mg of calcium daily. DESIGN Case report. SETTING University hospital. PATIENT A 58-year-old woman with MS and osteoporosis presenting with acute-onset tremors and confusion. MAIN OUTCOME MEASURES Serum calcium and 25-hy...

According to the importance of Apricots in families’ nutrition basket, food chain and also its increased greenhouse, measure three of the nutrient and biochemical factors of Apricots were done [1-23]. Within the frame work of a plan, the amount of Vitamin D2 (Ergocalciferol) and Vitamin D3 (Cholecalciferol) in greenhouse and ordinary Apricots were compared together, respectively. Then, we made ...

BACKGROUND Low levels of serum 25-hydroxy vitamin D are associated with increased arterial stiffness and hypertension. Supplementation with vitamin D precursors has been proposed as a treatment option for these conditions. We examined the effect of oral cholecalciferol on arterial stiffness and blood pressure in healthy normotensive adults. METHODS 40 healthy adults were randomised in this do...