An enormous and continually growing body of evidence associates genetic variation at the 9p21.3 locus with various phenotypes of coronary heart disease (CHD). What remains to be discovered is the precise phenotype(s) that 9p21.3 predicts, the underlying specific genetic and pathophysiological mechanisms involved, the possible and optimal application of 9p21.3 genotyping in risk prediction, and ...

The visual and somatic sensory cortex were investigated. The activity of acetylcholinesterase and lactate dehydrogenase was similar in the pretrigeminal and non-operated cats. The activity of these two enzymes, as well as that of choline acetyltransferase, butyrylcholinesterase and acid phosphatase was similar 3 and 8 h after the pretrigeminal transection. Results support the possibility of uti...

IT was shown by Mann & Quastel [1937] that choline is oxidized by slices or extracts of rat liver and kidney. The oxidation product was isolated and identified as betaine aldehyde. Some evidence was obtained that betaine aldehyde is also oxidized by the same tissues though at a much slower rate than choline and it was suggested that the oxidation product in this case is betaine. Bernheim & Bern...

We examined the effect of crotoxin, the neurotoxic complex from the venom of the South American rattlesnake Crotalus durissus terrificus, on the uptake of 3H-choline in minces of smooth muscle myenteric plexus from guinea pig ileum. In the concentration range used (0. 03-1 microM) and up to 10 min of treatment, crotoxin decreased 3H-choline uptake by 50-75% compared to control. This inhibition ...

OBJECTIVES Choline and folate metabolism disturbances may be involved in the occurrence of intrauterine fetal death (IUFD). The proper activity of this metabolism could be determined by genetic variants involved in choline pathway e.g. CHKA (gene encoding choline kinase α), PCYT1A (gene encoding CCTα) and CHDH (gene encoding choline dehydrogenase). Our study aimed at determining the genotype an...

two hundred and forty hubbard classic broiler chicks were used in a 35 day trial at chittagong veterinary and animal science university farm, bangladesh to study the effects of supplemental choline chloride on performance parameters, carcass characteristics and their association in commercial broiler. all birds had free access to ad libitum feeding. birds were fed four types of diet i.e. diet w...

Two hundred and forty Hubbard Classic broiler chicks were used in a 35 day trial at Chittagong Veterinary and Animal Science University farm, Bangladesh to study the effects of supplemental choline chloride on performance parameters, carcass characteristics and their association in commercial broiler. All birds had free access to ad libitum feeding. Birds were fed four types of diet i.e. diet w...