Choriocarcinoma is a highly malignant tumor that can arise from trophoblasts of any type of gestational event but most often from complete hydatidiform mole. IGF-II plays a fundamental role in placental development and may play a role in gestational trophoblastic diseases. Several studies have shown that IGF-II is expressed at high levels in hydatidiform moles and choriocarcinoma tissues; howev...

a 33-year-old female presented with intermittent abdominal pain and severe attacks of lower gastrointestinal (gi) bleeding since 2 weeks. she has had history of irregular menses in last 3 months. in the labeled rbc-scan study, the bleeding site was detected in left upper quadrant (luq). in surgery, a tumor with the diameter of 2ã—1cm in a 65 cm distance of ligament of trietz was detected. in pa...

INTRODUCTION Diverse sequelae of central nervous system metastasis of choriocarcinoma have been reported, including infarction, intra or extra axial hemorrhages, aneurysm formation and carotid-cavernous fistula. Here we report a case of subdural hematoma as the first presentation of choriocarcinoma. CASE PRESENTATION The patient is a 34-year-old woman whose initial presentation of widely meta...

Choriocarcinoma is an aggressive trophoblastic neoplasm; its origin could be gestational or non-gestational.  Most are gestational, which means they arise from pregnancy, may abnormal normal. This review includes the published literature about choriocarcinoma's prevalence and risk factors. The researchers searched Science Direct, PubMed, EBSCO, Web of Science, Cochrane library, Scopus....

Choriocarcinoma is a gestational trophoblastic disease that carries high mortality. As this disease is highly responsive to chemotherapy, early diagnosis could lead to a favorable outcome. We report a case of metastatic pulmonary choriocarcinoma presented with hemoptysis and respiratory failure in a young woman at her third trimester. This report discusses the dilemma in deriving the diagnosis ...

Introduction: Choriocarcinoma is a rare but highly malignant trophoblastic neoplasm. Cases of its coexistence with or after a “normal” pregnancy are extremely rare. Intraplacental choriocarcinoma is rare, and usually results in maternal metastasis at the time of diagnosis. Case presentation: We present the case of a 29 year-old gravida 1 para 0 Chinese woman who delivered a viable 3,140 g femal...

background: the pathogenesis of gestational trophoblastic disease (gtd) is not clearly known. objective: in this study, immunoexpression of proteins bcl-2 and beclin-1 in trophoblastic lesions and normal trophoblastic tissue was conducted to study the mechanism of apoptotic and autophagic cell death that is expected to complete the study of gtd pathogenesis. materials and methods: bcl-2 and bec...

Trophoblastic diseases are mainly hydatidiform mole and choriocarcinoma, where the latter is usually the sequela of molar pregnancy and malignant systemic disease with general metastases destructing various tissues and organs till she die. High level urinary hCG, real-time B-mode and color Doppler imaging detect hydatidiform mole in early gestation, postmolar persistent trophoblastic disease is...

OBJECTIVE To report the clinical characteristics, pathologic findings and treatments of a patient with a Caesarean scar choriocarcinoma. PATIENT HISTORY A 22-year-old woman had a diagnosis of primary gestational choriocarcinoma in a uterine Caesarean scar misdiagnosed as a normal Caesarean scar pregnancy. The patient underwent selective uterine artery embolization coupled with methotrexate ar...