This study investigated the potential role of sirtuin 1 in Müller glial cells in choroidal neovascularization. In the in vitro study, primary Müller glial cells were cultured and treated with resveratrol, a sirtuin 1 activator. Glial fibrillary acidic protein expression and angiogenesis-related gene expression were examined using quantitative polymerase chain reaction and phagocytosis, as a mar...

Choroidal osteoma is a unique tumor that comprises mature bone in the circumpapillary or macular region.1 Choroidal osteoma showed evolution with change in clinical features over many years, and cases of tumor growth, tumor decalcification or involution, and related choroidal neovascularization (CNV) were documented.1-4 Herein, we present a case of choroidal osteoma with serous retinal detachme...

PURPOSE To report choroidal thickness and volume in healthy eyes using swept source optical coherence tomography (SS-OCT). METHODS A prospective observational study of 122 patients examined with swept source OCT (DRI-OCT, Topcon, Japan). In each eye, we performed 256 horizontal scans, 12 mm in length and centered on the fovea. We calculated choroidal thickness manually with a built-in caliper...

PURPOSE To investigate the association between subfoveal choroidal thickness and ocular axial length, refractive error, and blood pressure in healthy young women and men. METHODS Cross-sectional observational study of 93 eyes in 93 healthy Danish university students (mean age 24.9 ± 2.6 years). The submacular choroid was imaged using enhanced-depth imaging spectral domain optical coherence to...

Focal choroidal excavation (FCE) was first reported as a choroidal posteriorly excavated zone without any scleral change. Choroidal excavation also divided into conforming and nonconforming type. Numerous reports demonstrated association between FCE and other disease such as choroidal neovascularization and central serous choroidoretinopathy. Here, we report a rare case of FCE in a patient with...

PURPOSE To study changes in choroidal thickness with ranibizumab treatment for choroidal neovascularization (CNV). DESIGN Prospective case series. METHODS This prospective study consisted of 60 CNV-affected eyes of 60 patients treated with intravitreal injections of ranibizumab using an on-demand protocol after an initial loading phase. The eyes studied included 20 with age-related macular ...

through the formation of early products such as Schiff base and Amadori rearrangement products, to the formation of advanced glycation endproducts (AGEs). Ne-(Carboxymethyl)lysine (CML), a major structure in AGEs, is accumulated in several tissues of human and animal during aging and various disease states including age-related macular degeneration (AMD). Choroidal neovascularization leads the ...

Purpose The purpose of this study was to characterize a novel finding that relative positions of choroidal and retinal vessels change over time in preterm infants and to identify factors associated with this finding using quantitative analysis. Methods Fundus images were obtained prospectively through a retinopathy of prematurity (ROP) cohort study. Images were excluded if choroidal vessels c...

OBJECTIVE To compare choroidal thickness between patients with type 2 diabetes (T2D) and healthy controls measured using swept-source optical coherence tomography (SS-OCT). METHODS The sample comprised 157 eyes of 94 T2D patients, 48 eyes of which had diabetic macular edema (DME), and 71 normal eyes of 38 healthy patients. Subfoveal (SF) choroidal thickness, and choroidal thickness at 500-μm ...

PURPOSE To evaluate subfoveal choroidal thickness in patients with central retinal vein occlusion (CRVO) using enhanced depth imaging optical coherence tomography. DESIGN Retrospective observational study. METHODS We measured bilateral subfoveal choroidal thickness, averaged for 100 scans, in 36 patients (mean age, 66 ± 15 years; 26 women and 10 men) with unilateral CRVO by using the enhanc...