objective(s): epigenetic regulation of gene expression can be carried out through chromatin remodeling enzymes such as swi/snf. brg1 also known as smarca4 is a catalytic subunit of swi/snf, which is necessary for mmps expression. matrix metalloproteinases (mmps) are known as important player enzymes during tumor progression and metastasis. aberrant epigenetic modification of chromatin should be...

Significance Mitogen-activated protein kinases (MAPKs) function in all eukaryotes signaling extracellular stimuli to intracellular responses and ultimately link them chromatin events by targeting transcription factors remodeling complexes. In plants, MAPKs play crucial roles immunity, development, stress responses, but so far no attempts have been made identify phosphorylation of chromatin-asso...

Background: It is showed that methamphetamine has harmful effects on male reproductive system. The aim of this study was to investigate the effects of methamphetamine administration on testis weight, sperm count, sperm morphology, and chromatin status as well as sperm apoptotis followed by the cytochemical tests in a mouse model. Materials and Methods: Twenty four NMRI male mice were divided in...

background: evaluating the significance and the effects of plant-derived drugs on laboratory animal’s fertility was recognized. there was antioxidant activity reported from heracleum persicum (golpar).objective: current study aims to study the antioxidant effect of golpar extracts on sperm parameters and chromatin quality in mice.materials and methods: eighteen adult male mice were divided to 3...

Background: Acrylamid (AA) is found in carbohydraterich foods that are prepared at high temperatures, such as French fries and potato chips. The toxic effects of AA in male animals include degeneration of epithelial cells of seminiferous tubules, decreased number of sperm and elevation in abnormal spermatozoa. The aim of this study was to evaluate the detrimental effects of AA on sperm paramete...

Background: Varicocele is commonly existed among infertile men and causes testis damage. Disorder of spermatogenesis was observed in varicocele individuals and leads to low quality sperm parameters and chromatin damage. Chromatin damage plays a critical role in pregnancy outcomes through in vitro or in vivo fertilization. Varicocelectomy considered as standard treatment of clinical varicocele. ...

introduction: different methods have been used to evaluate the beneficial effect of varicocelectomy; these include semen parameters and pregnancy rate. due to high biological variability of semen parameters, sperm functional test has been considered an efficient end point in assessment of fertility. therefore, the aim of this study was to evaluate the effect of varicocelectomy on semen paramete...

background: intrauterine insemination (iui) is one of the therapeutic approaches for infertility. the objective of this study was to evaluate dna integrity and apoptosis role in success of iui in both mild male and female factor infertility. methods: patients were divided into two groups: m (mild male factor; n=29) and f (female factor; n=31) undergoing single iui. ejaculates were analyzed and ...

Introduction Chromatin modifications and epigenetics are important pathogenesis mechanisms leading to various neurologic psychiatric disorders including epilepsy, drug addictions, depression, autistic spectrum, learning disabilities schizophrenia. Recently, the disruption of chromatin remodeling BAF complex has been linked several neurodevelopmental syndromes, commonly referred as PBAFopathies....