BACKGROUND Exposure to cotton is known to produce a specific occupational disease known as byssinosis. A large population of textile workers was investigated to determine whether such exposure was also associated with chronic bronchitis once other possible aetiological factors had been accounted for. METHODS A total of 2991 workers were investigated for the presence of symptoms compatible wit...

The epidemiology of chronic obstructive pulmonary disease (COPD) has been dominated by one hypothesis stating that cigarette smoking and chronic bronchitis were the key to pathogenesis and another that asthma, chronic bronchitis, and even emphysema are related to different expressions of a primary airway abnormality. The first hypothesis was rejected in the late 1960s based on a longitudinal st...

Vasoactive intestinal peptide (VIP) is a neuropeptide involved in the regulation of airway mucus secretion. The biological functions of VIP are mediated through two receptors, the vasoactive intestinal peptide receptor type 1 (VPAC1R) and type 2 (VPAC2R). The aim of this study was to quantify the expression of both VPAC1R and VPAC2R in the central airways of smokers with chronic bronchitis. Sur...

STUDY OBJECTIVE To investigate the predictive value of atopy, smoking, and living in a farm environment in the development of chronic bronchitis. DESIGN This was a cross sectional and longitudinal study. SETTING Postal surveys carried out in Finland in 1975 and 1981. PARTICIPANTS The study was part of the Finnish twin cohort study, which included adult twin pairs born in Finland before 19...

In 1960, Reid described a method of quantitating the bronchial mucous gland hypertrophy that occurs in chronic bronchitis. She expressed the bronchial mucous gland size as a ratio of the bronchial mucous gland thickness to the thickness of the bronchial wall, as measured from the epithelial basement membrane to the inner perichondrium. This ratio was increased in chronic bronchitis, and there w...

according to significant improvements in the tissue engineering field over the past several years, lung tissue cells have recently attracted more attention due to the high prevalence and diversity in related diseases. however, selection of an appropriate cell type, screening of suitable conditions for growth and proliferation, as well as subsequent implantation into the body to repair and regen...

Research on the association between chronic bronchitis and chronic obstructive pulmonary disease (COPD) exacerbations has led to discordant results. Furthermore, the impact of chronic bronchitis on mortality in COPD subjects is unclear.Within the Rotterdam Study, a population-based cohort study of subjects aged ≥45 years, chronic bronchitis was defined as having a productive cough for ≥3 months...