After acute brucellosis infection, symptoms persist in a minority of patients for more than 1 year. Such patients are defined as having chronic brucellosis. Since no objective laboratory methods exist to confirm the presence of chronic disease, these patients suffer delays in both diagnosis and treatment. The aim of the current study was to evaluate the usefulness of quantitative real-time PCR ...

Chronic brucellosis patients display a defective Th1 response to PHA. We have previously shown that heat-killed B. abortus (HKBA) can downregulate the PHA-induced increase of CD4+/CD25+ and CD14+/CD80+ cells of brucellosis patients. In the present study, we investigate the effect of E. coli LPS, as a potent stimulant of monocytes and autologous T-lymphocytes, on the PHA-cultured PBMCs of the sa...

Brucellosis is a highly contagious zoonosis affecting livestock and human beings. The human disease lacks pathognomonic symptoms and laboratory tests are essential for its diagnosis. However, most tests are difficult to implement in the areas and countries were brucellosis is endemic. Here, we compared the simple and cheap Rose Bengal Test (RBT) with serum agglutination, Coombs, competitive ELI...

Brucellosis is a common zoonotic infection caused by bacterial genus brucella. Brucellosis is an old disease known by various names including undulant fever or Mediterranean fever. This is one of the infectious diseases transmissible between animals and humans. Brucella bacteria multiply inside the body in some ways like swallowing, breathing, contact between damaged skin and slinked fetus or a...

introduction: brucellosis is one of the most common infectious diseases in some area of iran. it has very different clinical sings and symptoms, thus it should be considered in differential diagnosis of most infectious and non-infectious diseases. materials and methods: 415 brucellosis patients, who referred to imam khomeini and sina hospitals of tehran during 1998 to 2005, were studied from ep...

Brucellar septic arthritis has become extremely rare in Western developed countries since bovine brucellosis has been successfully eradicated. Nevertheless, we should remain vigilant for this disease, as brucellosis is still endemic in many parts of the world. The authors present the rare manifestation of a brucellar septic arthritis of the knee joint, associated with a lytic lesion of the prox...

Brucellosis remains prevalent in developing countries and results in substantial economic losses and human morbidity. The number of brucellosis cases increased in southeast Xinjiang provinces of China in recent years; however, the clinical epidemiological features of brucellosis in here are unclear. In this study, 160 patients with brucellosis in Bazhou People's Hospital between January 2014 an...

Brucellosis is a zoonotic disease transmitted to humans by animals infected with Brucella species. Brucella species are facultative intracellular bacteria consisting of aerobic gram-negative coccobacilli. Eight species of Brucella have been identified, including B. melitensis, B. abor-tus, B. suis, B. canis, B. ovis, B. neotomae, B. ceti, and B. pinnipe-dialis. 3 The three major pathogens causi...

Brucellosis is considered a zoonotic disease which is still an important health problem in endemic areas such as the Middle East, the Mediterranean, and Asia. Brucellosis is a sys‐ temic infection that might affect any organ or system in the body. Ocular involvement has been reported in 21% of brucellosis patients. The most common ocular manifestations of brucellosis were considered as anterior...

Brucellosis caused by various species of the genus Brucella is one most important zoonotic diseases global importance with veterinary, public health, and economic concerns. The study aimed to standardize IgM IgG-based iELISA detect anti-Brucella antibodies for serodiagnosis acute chronic human brucellosis. test was standardized using 1:320 dilution smooth lipopolysaccharide (sLPS) antigen from ...