An rodent animal model of pain offers a powerful tool in order to understand the mechanism involved in peripheral nerve injury for preclinical study of pain. A battery of neuropathic pain models has been developed to simulate the clinical pain conditions with diverse etiology. This article reviews some of the most widely used or promising new models for chronic pain. Partial spinal ligation, ch...

To study the neuropathic pain mechanism, various behavioral responses of animals in to different neuropathic models were considered. Adult male Sprague-Dawley rats weighing 230-280 g were used. Anesthesia was initially induced with pentobarbital I.P. (50 mg/kg). These models included (1): chronic constriction injury (CCI) by loose ligation of the sciatic nerve (2) Spared nerve injury (SNI) by a...

Baclofen, which is a specific agonist of the metabotropic GABA(B) receptor, is used in clinical practice for the treatment of spasticity of skeletal muscles. It also exerts an analgesic effect, but this effect is still not clear and especially controversial in neuropathic pain. In this work, we studied the antinociceptive effects of baclofen in a model of chronic peripheral neuropathic pain - l...

The amygdala is critical for the production of appropriate responses towards emotional or stressful stimuli. It has a characteristic neuronal activation pattern to acute stressors. Chronic pain and stress have each been shown independently modulate activity amygdala. Few studies investigated effect injury, on stress. This study effects neuropathic injury response an restraint constriction right...

Abstract Our previous research has shown that galanin plays an antinociceptive effect via binding to receptors (GalRs) in nucleus accumbens (NAc). This study focused on the involvement of GalR2 galanin-induced NAc neuropathic pain rats. The chronic constriction injury sciatic nerve (CCI) was used mimic model. hind paw withdrawal latency (HWL) thermal stimulation and threshold (HWT) mechanical w...