chronic granulomatous disease (cgd) is a rare inherited disorder characterized by inability of phagocytes to generate oxygen radicals needed for intracellular killing of phagocytic microorganisms. we report a 2.5-year-old iranian female with multiple liver abscesses. she was admitted in surgical ward because of abdominal pain and fever for one month duration that had no response to conventional...

conclusions in short term, using the self-management program can lead to increased exercise tolerance and decreased dyspnea in patients with copd; thus, this program is recommended as an effective way to improve the functional statuses of these patients. results there was no significant difference between the groups in exercise tolerance at base line; but, they were significantly different at t...

background: several studies have showed an increased prevalence of airflow obstruction in first degree relatives of individuals with chronic obstructive pulmonary disease (copd). considering no specific research had evaluated airway resistance in offspring of patients with severe copd, we utilized a spirometry and a impulse oscillometry (io) to evaluate this population. materials and methods: i...

background & aim: the aim of this clinical trial study was to evaluate sleep quality in patients with chronic lung disease and the role of controlled breathing to improve the quality of sleep. methods & materials: sixty-four patients with chronic lung disease in two group (experimental and control group) enrolled in a 7 weeks. before interventions, the pittsburgh sleep quality index (psqi) and ...

Background: There has recently been increasing interest in the role of the human microbiome in disease. Antibiotic use is known to disrupt the intestinal microbial environment and cause acute disease, for example pseudomembranous colitis. This study aimed to investigate the hypothesis that long-term antibiotic use is associated with the development of chronic diseases, i.e., Asthma, Rheumatoid ...

background: marjolin's ulcer is a rare, aggressive condition that arises on chronic skin lesions and diseases. in this article, we will report 83 cases of this disease. methods: retrospectively, we retrieved 83 records of patients with cancer arising from chronic skin conditions. data concerning demography, type of original skin insult, time interval between original lesion and cancer, can...

the bicuspid aortic valve is known to be the most common congenital cardiac malformation, with an approximate incidence rate of 1-2% in the general population. most patients are unaware of the disease until the onset of infective endocarditis, which is a life-threatening complication that may affect a heart valve or other cardiac structures at the site of endothelial damage. a 22-year-old man p...

chronic granulomatous disease (cgd), a rare inherited primary immunodeficiency disorder,  is  caused  by  mutation  in  any  one  of  the  genes  encoding  components   of nicotinamide adenine dinucleotide phosphate (nadph)-oxidase enzyme. ncf2 gene (encoding p67-phox component) is one of them and its mutation is less common to cause cgd (around 5-6%). here, we assessed mutation analysis of ncf...

abstract background: quality of life is a concept, which in recent years is considered as a measure for health in chronic diseases such as kidney diseases. complications of chronic diseases can affect the quality of life in children and their families over time. therefore, empowerment programs are necessary to improve their quality of life. this study aimed to investigate the impact of the fami...

background: mustard gas has different effects on different body systems such as respiratory tract, blood, gastrointestinal, skin, eye, endocrine and peripheral nervous system. objectives: the purpose of this study was to determine the quality of life in chemical warfare veterans due to sulfur mustard exposure. patients and methods: in a cross-sectional and analytic study, 242 patients who had a...