Medical advances in the management of patients with sickle cell disease, thalassemia, and other hemolytic anemias have led to significant increases in life expectancy. Improved public health, neonatal screening, parental and patient education, advances in red cell transfusion medicine, iron chelation therapy, penicillin prophylaxis for children, pneumococcal immunization, and hydroxyurea therap...

Chronic hemodialysis (HD) patients increase erythrocyte susceptibility to hemolysis and impair cell survival. We explored whether electrolyte-reduced water (ERW) could palliate HD-evoked erythrocyte impairment and anemia. Forty-three patients undergoing chronic HD were enrolled and received ERW administration for 6 month. We evaluated oxidative stress in blood and plasma, erythrocyte methemoglo...

Sickle cell disease (SCD) is a monogenic disease that causes a significant reduction in life expectancy due to the presence of chronic anemia, acute painful episodes and organic injuries. The most common chronic injuries are cardiopulmonary complications, such as pulmonary hypertension (HP), chronic lung disease, diastolic dysfunction and congestive heart failure (CHF), which are manifested mos...

2-Chlorodeoxyadenosine, a new lymphocyte-selective, anti-neoplastic drug was administered to 18 patients with advanced chronic lymphocytic leukemia of B-cell origin. All patients were resistant to conventional treatment. A total of 44 courses of 2-chlorodeoxyadenosine were completed with minimal toxicity. An overall response rate of 55% was achieved with four of 18 patients demonstrating partia...

By S. H. Liu, I\I.I). I N ‘FilE preceding paper,’ the diata of 2 cases of chronic anemia of the henlolytic type were presented. The erythrocytes in these cases were abnormally suseeptil)le to hemolysis by chilling and by addition of acid! in the presence of the patients’ as well as control sera. Erythrocytes from control subjects, in contrast, \V(9P not hemolvzed under identical t reat ment . T...

Autoimmune hemolytic anemia (AIHA) has been described in patients with lymphoid neoplasm with an etiologic relationship between the emergence of autoantibodies and lymphocyte dysfunction. Autoimmune disorders are less to develop in patients with other neoplasm like chronic myeloid leukemia, myelodysplastic syndrome or acute myeloid leukemia. Few reports have been documented the development of i...

By S. H. Liu, I\I.I). I N ‘FilE preceding paper,’ the diata of 2 cases of chronic anemia of the henlolytic type were presented. The erythrocytes in these cases were abnormally suseeptil)le to hemolysis by chilling and by addition of acid! in the presence of the patients’ as well as control sera. Erythrocytes from control subjects, in contrast, \V(9P not hemolvzed under identical t reat ment . T...

Activity of total lactate dehydrogenase (LDH) and that of the heat-stable isozyme (LDH-1) was measured by the method of Strandjord and Clayson in the serum of 62 cardiac patients with congenital and valvular heart disease before and after cardiac catheterization and at follow-up examination after cardiac surgery. A universal elevation of both total and heat-stable LDH was found in patients with...

Hemolysis in serum specimens is commonplace. This study examines the effect of hemolysis on results of selected chemical assays. Hemolysis was simulated by adding hemolysate to serum to give hemoglobin concentrations of 90 to 2800 mg/liter and a rating by technologists of 0 to 4 + hemolyzed. The effect of hemolysis on values for some serum constituents, particularly acid phosphatase and creatin...