Chronic mucocutaneous candidiasis (CMC) is characterized by a chronic or recurrent non invasive infection, mainly due to Candida albicans , in skin, nails, and mucous membranes, associated some cases with autoimmune manifestations. The key immune defect disruption of the action cytokine IL-17, whose most common genetic etiology STAT1 gene gain-of function (GOF) mutations. initial appropriate tr...

lichen planus (lp) is a chronic mucocutaneous disease widely recognized in adults, but uncommon in children. the purpose of this paper is to report two cases of lp in children. the diagnosis was made based on clinical and histopathological findings. the treatment consisted of antifungal and multivitamin therapy. regression of lesions was observed. the patients are still under follow up. althoug...

Introduction: Leishmaniasis is a neglected tropical disease caused by vector-borne protozoa of the genus Leishmania. Cutaneous and mucocutaneous forms result in disfiguration or mutilation, whilst visceral leishmaniasis (VL) affects multiple organs and is fatal if untreated. Notably, Leishmania are capable of establishing a chronic infection, which may reactivate years after initial infection w...

Lichen planus is an inflammatory, mucocutaneous disease that in addition to the skin involves oral mucosa in about 60-70 % of cases. In recent years, several reports have supposed a relationship between oral lichen planus (OLP) and chronic liver disease, especially hepatitis C (HCV). Here we present an extensive review of the literature in English that examines the association between HCV and OLP.

Background Chronic kidney disease (CKD)-associated mucocutaneous manifestations significantly impair the quality of life but often remain understudied. They may also vary across regions, socioeconomic and nutritional status, and racial differences. Objectives To study the patterns of mucocutaneous disorders and their prevalence in CKD patients irrespective of clinical stage or dialysis status...

Chronic mucocutaneous candidiasis (CMC) is a primary immunodeficiency characterized by persistent or recurrent skin and mucosal surface infections with Candida species. Different gene mutations leading to CMC have been identified. These include various heterozygous gain-of-function (GOF) mutations in signal transducer and activator of transcription 1 (STAT1) that are not only associated with in...

Rhinosporidiosis is a chronic granulomatous fungal disease caused by Rhinosporidiosis seeberi. It usually affects the mucocutaneous tissue of the nose; bone involvement is rare. We report the clinical features, diagnosis, and management of rhinosporidiosis involving the face, forehead, and right foot. As antimicrobial therapy was ineffective, a below-knee amputation was performed.