A 45-yr-old female presented with a ness in spite of a bone marrow biopsy rapidly enlarging bony tumor that was showing myelofibrosis and liver biopsy eventually identified as a Philadelphia documenting extramedullary hematopoiechromosome (Ph’)-positive myeloprolifersic. This case represents a unique constelative disorder with extramedullary blastic lation of features of the myeloproliferative ...

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the Western world. Host immune surveillance caused mainly by the disease itself is speculated to be responsible for high incidence of secondary neoplasms. However, the simultaneous occurrence of CLL and myeloproliferative disorder in the same patient is extremely rare. In the present report, a case of an 81-year-old man who...

Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the t(9;22) translocation coding for the chimeric protein p210 BCR-ABL. The tumor suppressor PTEN plays a critical role in the pathogenesis of CML chronic phase, through non genomic loss of function mechanisms, such as protein down-regulation and impaired nuclear/cytoplasmic shuttling. Here we demonstrate that BCR-...

A syndrome of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia/malignancy associated with t(8;13)(p11;q11): Description of a distinctive climicopathologic entity. Simultaneous occurrence of a T-cell lymphoma and chronic myeloid leukemia with an unusual karyotype. translocation breakpoints associated with an atypical myeloproliferative disorder: Evidence for three discreet loci invo...

Chronic myelomonocytic leukemia is a clonal stem cell disorder that is characterized mainly by absolute peripheral monocytosis. This disease can present myeloproliferative and myelodysplastic characteristics. According to the classification established by the World Health Organization, chronic myelomonocytic leukemia is inserted in a group of myeloproliferative/myelodysplastic disorders; its di...

AIMS To determine whether myeloid proliferation was monoclonal or polyclonal in a woman with chronic neutrophilic leukaemia and myeloma. METHODS The X-linked probe, M27 beta was used to determine the clonality of the neutrophil population by analysis of restriction fragment length polymorphisms and X inactivation pattern. RESULTS A polyclonal pattern of X inactivation was obtained for the n...

obsessive compulsive disorder (ocd) is a type of anxiety disorder characterized by recurrent, intrusive, unwanted thoughts. research indicates a genetic predisposition for ocd. many people with ocd have one or more family members who also have it or who may have other anxiety disorders influenced by the brain's serotonin levels, such as panic disorder. although ocd is a chronic and oftenti...

BACKGROUND AND OBJECTIVES Chronic myeloproliferative disorders (CMDs) are thought to be due to mutation(s) in a single clone at the level of the hematopoietic stem cell (HSC). Such mutations and additional mutations causing progression of the disease are largely unknown. Chronic myeloid leukemia (CML) is a CMD characterized by a chromosomal translocation between chromosomes 9 and 22 creating th...

The concurrence of myeloproliferative neoplasms (MPNs) and multiple sclerosis (MS) is unusual. We report five patients from a localized geographic area in Denmark with both MS and MPN; all the patients were diagnosed with MPNs in the years 2007-2012. We describe the patients' history and treatment. A potential link between MS and MPNs has not been previously recognized. This observation calls a...

Extensive fibrosis in myelodysplastic syndromes (MDS) is distinctly infrequent. Herein, we report three rare cases of hyperfibrotic MDS. This entity should be classified separately in the chronic myeloproliferative disease (CMPD)-MDS group due to variable clinical presentation and poor prognosis.