Subacute necrotizing sialadenitis is an inflammatory necrotizing lesion occurring in minor salivary glands. Most cases occur in the palatal region. In this article, we reported a 36-year-old man referred to our clinic as an emergency with the complaints of excessive bleeding, airway obstruction and hipovolemia. Intraorally, there was a hemorrhagic, protruding giant mass in the palatal region. F...

OBJECTIVES/HYPOTHESIS Immunoglobulin G4 (IgG4)-related sclerosing sialadenitis is a recently recognized disease entity characterized by high serum IgG4 concentration and IgG4-producing plasma cell expansion in affected organs, which show fibrotic or sclerotic changes. However, little is known about the roles of CD4+ and CD8+ T cells or interleukin (IL)-17 in this disease. The purpose of this st...

Many conditions affect the salivary glands. Acute sialadenitis is infectious or inflammatory disorders of the salivary glands. The exact frequency of submandibular sialadenitis is unclear. The acute conditions more typically involve the parotid and submandibular glands. During an acute inflammatory process, there is swelling of the affected gland, overlying pain, gland tenderness, fever, and on...

Malignant epithelial tumours associated with autoimmune sialadenitis are rare in white races but occur more often in those of Eskimo or oriental descent. Ultrastructurally these tumours are squamous in origin, and they may arise from the epithelial component of autoimmune sialadenitis. The two cases reported are the first described in natives of this country, and in one, a case of parotid tumou...

Background The Sjögren’s syndrome (SS) is a chronic autoimmune disease. classification criteria of SS have been evolved through the decades. Recent in 2016, American college rheumatology (ACR)–European Alliance Associations for Rheumatology (EULAR) requires at least one positive finding either labial salivary gland biopsy or anti-Ro (SSA) serology confirmation SS. Chronic sclerosing sialadeniti...

OBJECTIVE Secretory leukocyte proteinase inhibitor (SLPI) is an endogenous proteinase inhibitor present in mucosal secretions. It also displays antimicrobial activity including anti-human immunodeficiency virus activity. This protease inhibitor is also expressed in submandibular glands (SMG), but there are few data on its expression in AIDS patients with infectious conditions. METHODS We anal...

Salivary gland toxicity is a common adverse effect of radioactive iodine (131I) for the treatment of thyroid cancers with a prevalence ranging from 2% to 67% of the 131I exposed population. Recently, sialendoscopy has been introduced as an attractive diagnostic and therapeutic tool for management of patients with radioiodine-induced sialadenitis that is unresponsive to standard medical treatmen...

BACKGROUND Lipomas are benign neoplasms arising from adipose tissue. Oral lipomas have been reported in the buccal mucosa, tongue, floor of the mouth and lips; however, the case of a lipoma occurring as an antecedent lesion to recurrent sialadenitis is hitherto unreported in the English literature. CASE PRESENTATION We report the case of an intraoral lipoma occurring with signs and symptoms o...