Hyperalgesia is a common clinical phenomenon among opioid dependent patients on methadone maintenance therapy (MMT) and it may be associated with undertreated pain and/or therapeutic failure. This study aimed to investigate association between serum methadone concentration (SMC) and cold pressor pain responses. Cold pressor pain responses in 147 opioid dependent patients on MMT were assessed us...

background: occupational diseases are worldwide. some dentists believe that they are at a higher risk for development of some musculoskeletal disorders for the postures they should have during work. objective: to determine the prevalence of musculoskeletal pain and their associated occupational factors among dentists from shiraz, southern iran. methods: in a cross-sectional study, 90 dentists o...

introduction: low back pain is the most common musculoskeletal complication. although there are many ways to treat low back pain, achieving a concise, simple, and compact method is required in today's industrial societies. the purpose of this study was to evaluate the effect of six weeks selected core stabilization exercises on pain and functional disability in patients with nonspecific chronic...

background: phantom limb pain (plp) is approximately a common condition after limb amputation, which potentially affects the quality of life. we aimed to evaluate anxiety and depression in patients with amputated limbs suffering from plp and to compare these psychological dysfunctions with that of patients with non‑phantom chronic pain. methods: a total number of 16 male amputees with plp and 2...

aim and background: psychological factors have a pivotal role in the chronicity of diseases. chronic pain may lead to depression and disabilities in patients, which may change their quality of life and life style. the aim of this study was to evaluate the relationship between coping strategies, depression, physical disability, and pain intensity in people with chronic back pain. method and mate...

bulbospinal noradrenergic pathways are shown to have an important role in descending inhibition of pain sensation. locus ceruleus (lc), as a rich noradrenergic nucleus in the brain stem which has projections into the dorsal horn of the spinal cord, was evaluated for antinociceptive activity by using tonic and phasic pain models in the rat. lc-lesioned rats demonstrated moderate increase in both...

objectives: this study aimed at investigating the effectiveness of mindfulness based cognitive therapy (mbct) in management of pain and functional limits of chronic pain patients. methods & materials: in this semi-experimental study, 30 volunteer female patients suffering from chronic pain attending a clinical assessment for treatment of chronic pain were recruited using the convenience samplin...