A highly regio- and stereo-selective synthesis of cyclic β-D-glucosides 3 via Pd(0)-catalyzed coupling cyclization of allenyl β-D-glucoside 1 and organic iodides in 20-38% yields is reported. After the deacetylation of 3, we obtained cyclic β-D-glucoses 4 in 90-97% yields, which may have SGLT2 inhibition activities.

Compound xueshuantong capsule (CXC) is an oral traditional Chinese herbal formula (CHF) comprised of Panax notoginseng (PN), Radix astragali (RA), Salvia miltiorrhizae (SM), and Radix scrophulariaceae (RS). The present investigation was designed to explore the core bioactive components promoting blood circulation in CXC using high-performance liquid chromatography (HPLC) and animal studies. CXC...

Hibiscus syriacus is a highly ornamental flowering shrub widely grown in East Asia. Its abundant flower colors mainly reflect the accumulation of anthocyanins. Classifying H. petals and identifying relationship between color anthocyanins can provide references for breeding. With eight cultivars as experimental materials, floral was described using Royal Horticultural Society Color Chart CIEL*a*...

The present study examined modifications of β-naphthoflavone (β-NF)-induced cytochrome P450 1A1 (CYP1A1) expression by flavonoids in mouse hepatocytes in primary culture. Some flavonoids (apigenin, chrysin, flavone, flavanone, galangin, luteolin, and naringenin) by themselves induced CYP1A1 mRNA expression, especially flavone which was even more effective than β-NF. The effect on β-NF-induced C...

From the water-soluble portion of the methanol extract of stems of Ficus tikoua Bur., a new benzofuran glucoside, named 6-carboxyethyl-5-hydroxybenzofuran 5-O-β-d-glucopyranoside (1), together with one known benzofuran glucoside (2) were isolated. Their structures were elucidated by 1D and 2D ((1)H-(1)H COSY, HMQC, and HMBC) NMR spectroscopy and HRMS techniques. The antioxidant activities of th...

A UDP glucosyltransferase from Bacillus licheniformis was overexpressed, purified, and incubated with nucleotide diphosphate (NDP) d- and l-sugars to produce glucose, galactose, 2-deoxyglucose, viosamine, rhamnose, and fucose sugar-conjugated resveratrol glycosides. Significantly higher (90%) bioconversion of resveratrol was achieved with α-d-glucose as the sugar donor to produce four different...

Objectives: We investigated the isoflavone contained in SH003 and its fractions, effect of these components on inhibition breast cancer.Methods: The isoflavones solvent fractions extract were identified by UPLC-MS contents quantified using HPLC analysis. estrogenic activity or was assessed ERE luciferase assay estrogen receptor (ER)-positive MCF-7 cells. To test cancer inhibitory effect, cell v...

ABSTR ACT: Resveratrol was glucosylated to its 3and 4′-β-glucosides by the glucosyltransferase PaGT3 from Phytolacca americana expressed in Bacillus subtilis. PaGT3 glucosylated pterostilbene to its 4′-β-glucoside. Piceatannol was converted into its 4′-β-glucoside by PaGT3. Resveratrol 3-β-glucoside showed the inhibitory action of adhesion, migration, and invasion of KB cells. The resveratrol 3...

The flowers of Chrysanthemum morifolium Ramat. have been used as an herbal tea and in traditional medicine, and the plant has been developed to produce horticultural cultivars of various colors and shapes. In this study, a new chrysanthemum cultivar with dark purple petals (C. morifolium cv. ARTI-Dark Chocolate; ADC) was developed by radiation-induced mutation breeding of its original cultivar ...

Activity-guided isolation of a methanolic extract of Galla Rhois using pancreatic lipase and 3T3-L1 adipocytes led to the isolation of seven phenolic compounds: protoaphin-fb (1), 2-O-digalloyl-1,3,4,6-tetra-O-galloyl-β-D-glucose (2), 1,2,3,4,6-penta-O-galloyl-β-D-glucose (3), 1,2,4,6-tetra-O-galloyl-β-D-glucose (4), 3-hydroxy-5-methoxy-phenol 1-O-β-D-glucoside (5), methylgallate (6), and galli...