نتایج جستجو برای: circulating tumor cells

تعداد نتایج: 1690461  

2015
Shigeshi Ono Stella Lam Makoto Nagahara Dave S. B. Hoon Takahiro Ochiya Ryou-u Takahashi

An increasing number of studies have focused on circulating microRNAs (cmiRNA) in cancer patients' blood for their potential as minimally-invasive biomarkers. Studies have reported the utility of assessing specific miRNAs in blood as diagnostic/prognostic biomarkers; however, the methodologies are not validated or standardized across laboratories. Unfortunately, there is often minimum limited o...

Journal: :The New England journal of medicine 2013
Sarah-Jane Dawson Dana W Y Tsui Muhammed Murtaza Heather Biggs Oscar M Rueda Suet-Feung Chin Mark J Dunning Davina Gale Tim Forshew Betania Mahler-Araujo Sabrina Rajan Sean Humphray Jennifer Becq David Halsall Matthew Wallis David Bentley Carlos Caldas Nitzan Rosenfeld

BACKGROUND The management of metastatic breast cancer requires monitoring of the tumor burden to determine the response to treatment, and improved biomarkers are needed. Biomarkers such as cancer antigen 15-3 (CA 15-3) and circulating tumor cells have been widely studied. However, circulating cell-free DNA carrying tumor-specific alterations (circulating tumor DNA) has not been extensively inve...

2014
Sanne de Wit Guus van Dalum Leon W M M Terstappen

The increasing number of treatment options for patients with metastatic carcinomas has created an accompanying need for methods to determine if the tumor will be responsive to the intended therapy and to monitor its effectiveness. Ideally, these methods would be noninvasive and provide quantitative real-time analysis of tumor activity in a variety of carcinomas. Assessment of circulating tumor ...

2012
Guus van Dalum Linda Holland Leon WMM Terstappen

Cancer is a prominent cause of death worldwide. In most cases, it is not the primary tumor which causes death, but the metastases. Metastatic tumors are spread over the entire human body and are more difficult to remove or treat than the primary tumor. In a patient with metastatic disease, circulating tumor cells (CTCs) can be found in venous blood. These circulating tumor cells are part of the...

2017
Mili Jain Ashutosh Kumar Sanjay Mishra Nishant Verma Madhu Mati Goel

A 2-year-old girl presented with fever, hepatomegaly, and progressively increasing proptosis of the right eye for 1 month. Abdominal ultrasound revealed a well-defined multi-lobulated predominantly hyperechoic mass lesion of 10.9x2.5x6.1 cm with a few foci of coarse calcification and small cystic areas arising from the right suprarenal region. The lesion was inferiorly compressing the renal par...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009
Karen Bluemke Udo Bilkenroth Axel Meye Susanne Fuessel Christine Lautenschlaeger Steffen Goebel Andres Melchior Hans Heynemann Paolo Fornara Helge Taubert

PURPOSE The aim of this study was to evaluate the clinical relevance of the presence of disseminated tumor cells in peripheral blood (so-called circulating tumor cells) for renal cell carcinoma patients. METHODS Two hundred thirty-three peripheral blood samples from 154 renal cell carcinoma patients were investigated for the presence of disseminated tumor cells by autoMACS technique and immun...

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