Adverse effect of conventional chemotherapeutic agent using single anticancer drugs had led to application combination therapy in cancer treatments. Combination polyphenolic compounds and was studied shown promising outcomes vitro. In treatment, mode cell death through apoptosis is one the targeted approaches many preclinical drug development studies has been identified as a key mechanism chemo...

Objective(s): The present study aims to evaluate the protective effect of the compounds isolated from Echinophora cinerea (E. cinerea) against oxidative stress and apoptosis induced by cisplatin (CIS) in PC12 cells. Materials and Methods: Six compounds were isolated as quercetrin-3-O-β-D-glucopyranoside (QUE), osthol (OST), verbenone-5-O-β-D-glycopyranoside (VER), Isoimperatorin (ISO), kaempfer...

The present work concerns with an investigation on the solubility of cis,cis-muconic acid dissolution in different polar solvents by characterizing and modeling the dissolution as a function of temperature. Water, ethanol, 2-propanol and acetic acid have been investigated as solvents in the range temperatures from a 298.15 to 348.15 K. Owing to the absence of cis,cis-muconic acid solubility...

Four new cis-dioxomolybdenum(VI) complexes of the closed formula [MoO2(L)CH3OH] have been obtained by condensation bis(acetylacetonato)dioxomolybdenum(VI) with S-allyl/propyl thiosemicarbazones in methanol. The compounds were identified elemental analysis, and molecular characterization UV-Vis, FT-IR, 1H-NMR 13C-NMR spectroscopies. Also, crystal structures 1 2 resolved X-ray diffraction analysi...

In the structure of the title molecular salt, C(5)H(7)N(2) (+)·C(8)H(11)O(4) (-), the cis monoanions associate through short O-H⋯O hydrogen bonds in the carb-oxy-lic acid groups [graph set C(7)], forming zigzag chains which extend along the c axis. These are inter-linked through pyridinium and amine N-H⋯O hydrogen bonds, giving a three-dimensional network structure.

In the structure of the title compound, NH(4) (+)·C(8)H(11)O(4) (-), the carboxyl and carboxyl-ate groups of the cation adopt C-C-C-O torsion angles of 174.9 (2) and -145.4 (2)°, respectively, with the alicyclic ring. The ammonium H atoms of the cations give a total of five hydrogen-bonding associations with carboxyl-ate O-atom acceptors of the anion which, together with a carboxyl O-H⋯O(carbox...

This study reports, for the first time, chemical composition and biological activity of essential oil from Brazilian Cymbopogon densiflorus flowers. Thirty compounds were identified by gas chromatography coupled with mass spectrometry (GC/MS), corresponding to 95 % total an chromatogram obtained chromatography-flame ionization detection (GC-FID ). The was mainly composed cis-p-mentha-1(7),8-die...

In the crystal structure of the title mol-ecular adduct, C(9)H(7)N·C(8)H(12)O(4), the two species are -linked through a carb-oxy-lic acid-isoquinoline O-H⋯N hydrogen bond. These mol-ecular pairs then inter-associate through the second acid group of the cis-cyclo-hexane-1,2-dicarb-oxy-lic acid molecules, forming a classic centrosymmetric cyclic head-to-head carb-oxy-lic acid-carboxyl O-H⋯O hydro...