The investigation of cis-PtI2(NH3)2, the diiodido analogue of cisplatin (cisPtI2 hereafter), has been unjustly overlooked so far mainly because of old claims of pharmacological inactivity. Some recent - but still fragmentary - findings prompted us to reconsider more systematically the chemical and biological profile of cisPtI2 in comparison with cisplatin. Its solution behaviour, interactions w...

Recently synthesized by the group of Sadler, the platinum(IV) diazido complexes [Pt(N(3))(2)(OH)(2)(L')(L'')] (L' and L'' are N-donor ligands) have potential to be used as photoactivatable metallodrugs in cancer chemotherapy. In the present study optimized structures and UV-Vis electronic spectra of trans,trans,trans- and cis,trans,cis-[Pt(N(3))(2)(OH)(2)(NH(3))(2)] (1t and 1c, respectively) as...

Transition-metal complexes bearing fluorinated phosphane and thiolate ligands has been an area of study in recent years and the chemical context of the current work is related to the metal-assisted functionalization of fluorinated derivatives. The cis and trans isomers of the square-planar complex bis[(pentafluorophenyl)diphenylphosphane-κP]bis(2,3,5,6-tetrafluorobenzenethiolato-κS)platinum(II)...

The reaction of cis-[MCl2(dppm)] (M ) Pt(II) and Pd(II); dppm ) bis(diphenylphosphino)methane) with H2TT and NaOH (H2TT ) 8-thiotheophylline) yields neutral mononuclear [M(HTT-S(8))2(dppm)] complexes. Homodinuclear [M(μ-TT-N(7),S(8))(dppm)]2 (M ) Pt(II) and Pd(II)) are prepared either by the reaction of [M(HTT)2(dppm)] with cis-[MCl2(dppm)] and NaOH or by the direct reaction of cis-[MCl2(dppm)]...

In this study the interaction of cis-PtCl2(NH3)2 complex and graphene were investigated with MPW1PW91method in gas and solvent phases. The solvent effect was examined by the self-consistent reaction fieldtheory (SCRF) based on Polarizable Continuum Model (PCM). The selected solvents were chloroform,chlorobenzene, bromoethane, dimethyldisulfide, and dichloroethane. The solvent ...

Pt(II) azido complexes [Pt(bpy)(N(3))(2)] (1), [Pt(phen)(N(3))(2)] (2) and trans-[Pt(N(3))(2)(py)(2)] (3) incorporating the bidentate diimine ligands 2,2'-bipyridine (bpy), 1,10-phenanthroline (phen) or the monodentate pyridine (py) respectively, have been synthesised from their chlorido precursors and characterised by X-ray crystallography; complex 3 shows significant deviation from square-pla...

In the title compound, cis-[PtCl(2)(C(5)H(13)N(3))(C(2)H(6)OS)], the four-coordinate Pt(II) atom is bonded to one N atom of the N,N,N',N'-tetra-methyl-guanidine ligand, one dimethyl sulfoxide S atom and two chloride ligands, forming a cis-square-planar geometry. The bond lengths and angles of the N-Pt-Cl functionality are typical for imine dichloridoplatinum(II) complexes. The H atom of the imi...

The synthesis, NMR characterization, and X-ray crystallography of "lantern-shaped" platinum(III) complexes with four pivaloamidate bridging ligands and two 9-ethylguanines (9-EtG) or 1-methylcytosines (1-MeC) in axial positions are reported: cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(9-EtG)(2)](NO(3))(2) and cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(1-MeC)(2)](NO(3))(2). The last complex is, to the best o...

The title compound, [PtCl(2)(C(18)H(12)Cl(3)P)(2)]·C(2)H(3)N, packs as monomeric units with a square-planar geometry around the Pt(II) atom. The two tris-(4-chloro-phen-yl)phosphane ligands are coordinated in a cis orientation, with P-Pt-P and Cl-Pt-Cl angles of 99.36 (2) and 88.02 (2)°, respectively. In the crystal, C-H⋯N inter-actions are observed between the phenyl rings and the acetonitrile...