The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of these isolated neurons. Their profiles were similarly enriched in cell-type-specific enhancers of genes implicated in neural develo...

Anti-MHC class I alloantibodies have been implicated in the process of acute and chronic rejection because these Abs can bind to endothelial cells and transduce signals leading to the activation of cell survival and proliferation pathways. To characterize the role of the MHC class I-signaling pathway in the pathogenesis of Ab-mediated rejection, we developed a mouse vascularized heterotopic car...

One of the long standing problems is a quest for regular black hole solutions, in which resolution spacetime singularity has been achieved by some physically reasonable, classical field, before one resorts to quantum gravity. The prospect using nonlinear electromagnetic fields this goal limited Bronnikov's no-go theorems, focused on Lagrangians depending invariant $F_{ab}F^{ab}$ only. We extend...

The interval temporal logic AB features two modalities that make it possible to access intervals which are adjacent to the right of the current interval (modality 〈A〉) and proper subintervals that have the same left endpoint of it (modality 〈B〉). AB is one of the most significant interval logics, as it allows one to express meaningful (metric) properties, while maintaining decidability (undecid...

antivenoms have been used successfully for more than a century and up to now constitute the only effective treatment for snakebites .the production of antivenin started long time ago when the calmette was prepared the antivenom in 1894.the method currently used to prepare antivenom by most of the manufacturers are originated from the method of pope which was develop in 1938. several new appr...

The finding that MHC class I molecules are physically associated with the TAP transporter has suggested that peptides may be directly transported into the binding groove of the class I molecules rather than into the lumen of the endoplasmic reticulum (ER) where they subsequently would encounter class I molecules by diffusion. Such a mechanism would protect peptides from peptidases in the ER and...

Vascular endothelial cells regulate the passage of fluids, solutes, and cells from the vascular space to the tissues. Disruption of vascular integrity is involved in the pathogenesis of inflammatory diseases including transfusionrelated acute lung injury (TRALI), a most severe nonhemolytic transfusion reaction with symptoms such as dyspnea and/or hypotension and fever. Pulmonary edema, due to i...

A new design approach for three-stage operational amplifiers (op-amps) is proposed. It allows to actually implement a symmetrical push-pull class-AB amplifier output stage for wellestablished three-stage amplifiers using a feedforward transconductance stage. Compared with the conventional design practice, the proposed approach leads to a significant improvement of the symmetry between the posit...

A novel CMOS operational transconductance amplifier (OTA) is presented, using a fully differential singlestage core OTA as input stage and a differential to single current converter as output stage, each biased at a separate current level. A large gain-bandwidth (GBW) product (2.7 MHz) and a high slew-rate (5 V//.LS) can be obtained by applying a large bias current to the core OTA. Due to the c...