I read in your Journal, with great interest, the paper by Veiga and coworkers about two cases of clear cell acanthomas located in the nipple area, with histological and immunohistochemical studies. They claim in the discussion, that only five cases had been previously described in the English literature and all affecting Korean women. Four of these cases mimicked chronic eczema. Two new cases w...

Although uncommonly diagnosed, clear cell acanthoma represents an original source of speculative interest for dermatologists. Due to its clinical variability, it is often only recognized accidentally after histology. Dermoscopy has improved the reliability of clinical diagnosis of typical clear cell acanthoma thanks to the vascular pinpoint pattern and desquamative, peripheral collarette. Gener...

Chondrosarcomas constitute 1-3% of all head and neck tumors. 2% of all chondrosarcomas are of the “clear cell” variety which follows a locally aggressive, relatively indolent course without predominant invasion of soft tissue. We present a case of a 45-year-old woman who presented with a aggressive variant of clear cell chondrosarcoma.

Intussusception in adults is a rare clinical entity. The individual surgeon will not often encounter this condition. A lead-point for adult intussusception exists in 90% of cases and is frequently malignant. We present four cases and discuss treatment and diagnostic modalities. A comprehensive review of the literature is given. All cases were treated by resection according to oncologic principl...

PURPOSE Increased expression of tissue factor (TF), a primary initiator of the extrinsic coagulation pathway, has been associated with a worse prognosis in a variety of solid tumors. We report for the first time the correlation of the immunohistochemical expression of tissue factor with clinical and pathological outcomes in clear cell carcinomas of the kidney. MATERIALS AND METHODS immunohist...

The incidence of male urethral cancer is rare with age preponderance of 50 to 60 years. The standard management approach is surgery. Here, we present a novel treatment approach for male urethral cancer. Thirty-six year old male, case of primary clear cell adenocarcinoma of urethra who refused surgery, underwent cystoscopic assisted intraluminal HDR brachytherapy. Patient received a dose of 36 G...

•Although patterns of metastases in ovarian clear cell cancer are not well described, patients may initially present with bone metastases.•Clear cell carcinoma with bone metastases is responsive to radiation therapy.•Bone metastases are not common in patients with ovarian high grade serous cancer.

Recently, studies have reported that long noncoding RNAs (lncRNAs) can act as modulators of mRNAs through competitively binding to microRNAs (miRNAs) and have relevance to tumorigenesis as well as other diseases. Identify lncRNA competitively regulated subpathway not only can gain insight into the initiation and progression of disease, but also help for understanding the functional roles of lnc...