gliobalstoma multiforme (gbm) or grade 4 astrocytoma is the most malignant form of primary brain tumor. treatment of glioblastoma is difficult despite of surgery, radiotherapy and chemotherapy. patients with glioblastoma survive for less than 12 months. considering to biology function of glioblastoma, researchers have recently offered new therapeutic approaches such as cannabinoid therapy for g...

the aim of this study was to assess the efficacy and tolerability of the aqueous extract of echium amoenum in combination with ssris in patients with general anxiety disorder (gad). the study was an 8-week double-blind randomized clinical trial. thirty-seven adult outpatients who met the dsm-iv-tr criteria for gad based on the structured clinical interview participated in the trial. in this stu...

topical retinoids are considered as the first line therapy in the treatment of acne vulgaris, but they are associated with cutaneous irritation. in this study, isotretinoin-loaded solid lipid nanoparticles(it-sln) were prepared to treat the mild to moderate acne. also using it-sln would minimize it adverse effects in comparison to commercial product, isotrex®. this study was conducted to prepar...

aim and background: patients with ischemic heart disease in acute stage experienced great anxiety and in compared with patients had less anxiety were affected 5 times more to ischemia, re-infarction, tachycardia, arrhythmias and ventricular fibrillation.  excessive anxiety delays recovery and increases the probability of their death in the first month. numerous studies have shown that heart dis...

normal 0 false false false en-us x-none ar-sa background: high prevalence of obesity and the importance of this issue as a risk factor for chronic diseases such as severe cardiovascular diseases, diabetes, and cancer necessitate the need for treatment. the aim of this study was the evaluation of acarbose effect on the weight loss in non-diabetic overweight or obese patients in kerman. materials...

primary dysmenorrhea refers to painful cramps during menstruation with no organic reason. with respect to its high incidence and adverse outcomes in quality of life and some evidences regarding the sedative and antispasmodic effects of melissa officinails on smooth muscles as an herb, this double-blind clinical trial was conducted to determine the effects of its capsules on severity of dysmenor...

Variance estimators are derived for estimators of the average lead time and average benefit time due to screening in a randomized screening trial via influence functions. The influence functions demonstrate that these estimators are asymptotically equivalent to the mean difference, between the study and control case groups, in the survival times. For estimating benefit time, the survival time i...

Acute viral infections pose many practical challenges for the accurate assessment of the impact of novel therapies on viral growth and decay. Using the example of influenza A, we illustrate how the measurement of infection-related quantities that determine the dynamics of viral load within the human host, can inform investigators on the course and severity of infection and the efficacy of a nov...

In the case of manufactured products, there are situations where some components of a product are produced over a period of time by collecting items from different vendors, using different raw materials, machines, and manpower. The physical characteristics and the reliabilities of such components may be different, but sometimes it is difficult to distinguish them clearly. In such situations, mi...

Early life adversity can have a significant long-term impact with implications for the emergence of psychopathology. Disruption to mother-infant interactions is a form of early life adversity that may, in particular, have profound programing effects on the developing brain. However, despite converging evidence from human and animal studies, the precise mechanistic pathways underlying adversity-...