Objective: The present study was aimed to develop topical gel of Clobetasol propionate with the help of carbopol-934 and Hydroxypropyl methylcellulose K4m as gelling agents. Polymers play major role in various characterization parameters of topical gel such as in vitro release and rheological properties. Methods: Gels were prepared with carbopol-934 and Hydroxypropyl methylcellulose K4m as gell...

The most widely prescribed drugs for the treatment of a variety dermatoses are Topical corticosteroids (TC). These medications approved inflammatory and pruritic manifestations dermatologic disorders due to their powerful symptom-relieving impact. Clobetasol propionate (CP) is popular (TC) used relieve itching, redness, oedema caused by skin disorders. Anti-inflammatory, anti-pruritic, vasocons...

Clobetasol propionate (CP) is a potent topical corticosteroid that causes several cutaneous and systemic side effects. In the present work, CP was encapsulated in nanostructured lipid carriers (NLCs) to increase drug retention in the outer skin layers and improve the safety of topical therapy. NLCs were prepared using a microemulsion technique with a mixture of lecithin, taurodeoxycholate, stea...

Background: Vulval lichen planus (VLP) is a debilitating, often treatment resistant condition, for which there is limited evidence-based guidance on assessment and management. Aim: To describe current management of women with VLP in the multi-disciplinary vulval dermatology clinic at the Royal Women’s Hospital (RWH), Melbourne, to compare this with reported practices in the literature and provi...

A 16 years old female patient, affected by atopic dermatitis and rhinoconjunctivitis allergica since childhood, requested a dermatologic consultation for lesions which had appeared after 3 months of local treatment with clobethasole propionate. The histological analysis confirmed the diagnosis of dyshidrotic eczema and the microbiological smears demonstrated a significant infection with Staphyl...

Thirty-nine patients (15 outpatients and 24 inpatients) with a variety of skin diseases affecting variable areas of the body surface were treated with clobetasol propionate ointment (Dermovate). Before and after treatment the adrenal response to an intramuscular injection of tetracosactrin was rested and additional 9 am plasma cortisol levels were measured at intervals during treatment. A satis...

INTRODUCTION Topical glucocorticoids (TG) are the most frequently prescribed drugs by dermatologists. Their clinical effectiveness in the treatment of psoriasis and atopic dermatitis is related to their vasoconstrictive, anti-inflammatory, immunosuppressive and anti-proliferative effects. Despite their benefit in the therapy of inflammatory diseases, TG are associated number of side effects tha...

Background: Pemphigus vulgaris (PV) is an autoimmune bullous disorder that is fatal if left untreated. High dose systemic corticosteroids are the basis of therapy. The addition of immunosuppressive agents has improved the disease outcome and reduced the required corticosteroid dose and related toxicity. Mycophenolate mofetil is increasingly used as a steroid-sparing agent in immunotherapy of PV...

Sir, Nail psoriasis affects 20–55% of psoriatic patients. It often represents a significant cause of distress because of the visible lesions and the chronic course of the disease. Treatment options include corticosteroids, vitamin D3 analogues, 5-fluorouracil, urea, anthralin, cyclosporine and radiotherapy (1). Tazarotene is an acetylenic retinoid with documented therapeutic results in skin pso...