PURPOSE: To evaluate the clinical activity of a sequential treatment with Adriamycin followed by CMF (cyclophosphamide, methotrexate, fluorouracil) and the relative therapeutic contribution of the two drug regimens given at full conventional doses in metastatic breast cancer. PATIENTS AND METHODS: From August 1990 to February 1993, 44 patients with advanced breast cancer previously untreated wi...

OBJECTIVE To estimate the health and economic impact of feeding partially hydrolyzed formula-whey (PHF-W) instead of standard cow's milk formula (CMF) for the first 4 months of life among US infants at high risk for developing atopic dermatitis (AD). STUDY DESIGN A Markov model was developed integrating published data, a survey of US pediatricians, costing sources and market data, and expert ...

The channel matched filter (CMF) is the optimum receiver providing the maximum signal to noise ratio (SNR) for the frequency selective channels. The output intersymbol interference (ISI) profile of the CMF convolved by the channel can be blindly obtained by using the autocorrelation of the received signal. Therefore, the inverse of the autocorrelation function can be used to equalize the channe...

OBJECTIVE A cross-sectional study to determine the pattern of craniomaxillofacial (CMF) injuries among children involved in road traffic crashes was performed. The association of protective equipment use with the CMF injuries was evaluated. METHODS Retrospective records of children treated in the University Malaya Medical Centre, Kuala Lumpur, Malaysia, after road traffic crashes between Janu...

BACKGROUND Results from three National Surgical Adjuvant Breast and Bowel Project sequentially conducted randomized trials of postoperative chemotherapy in women with estrogen receptor-negative tumors and negative axillary lymph nodes have demonstrated that a combination of methotrexate and 5-fluorouracil (MF) is more effective than surgery alone, that cyclophosphamide with MF (CMF) is more eff...

Aims. We examine the recoverability and completeness limits of the dense core mass functions (CMFs) derived for a molecular cloud using extinction data and a core identification scheme based on two-dimensional thresholding. We study how the selection of core extraction parameters affects the accuracy and completeness limit of the derived CMF and the core masses, and also how accurately the CMF ...

The Highways Agency (HA) has recently rethought the way it commissions maintenance work on the trunk roads and motorways for which it is responsible. Taking on recommendations from recent reports into the UK construction industry, the HA have introduced the Construction Management Framework (CMF) in Areas 9 and 10 which covers a large area of the UK from Herefordshire to Lancashire. The CMF loo...

In this paper, a new two-way relaying scheme based on compute-and-forward (CMF) framework and relay selection strategies is proposed, which provides a higher throughput than the conventional two-way relaying schemes. Two cases of relays with or without feedback transmission capability are considered. An upper bound on the computation rate of each relay is derived, and based on that, a lower bou...

OBJECTIVES A better understanding of the essential components of frailty is important for future developments of management strategies. We aimed to assess the incremental validity of a Comprehensive Model of Frailty (CMF) over Frailty Index (FI) in predicting self-rated health and functional dependency amongst near-centenarians and centenarians. DESIGN Cross-sectional, community-based study. ...

OBJECTIVE To assess the long term effectiveness of adjuvant treatment with cyclophosphamide, methotrexate, and fluorouracil (CMF) in patients with operable breast cancer at risk of relapse, on the basis of three successive randomised trials and one observational study conducted from June 1973 to December 1980. DESIGN Cohort study. SETTING Istituto Nazionale Tumori in Milan, Italy. MAIN OU...