Was the key dependent variable operationalized via standardized scale 100.0% or other appropriately established method? Were the conclusions justified by the data/findings? 100.0% Was (were) the sampled population(s) appropriate to the study aims/hypotheses (e.g., patient groups justified, presence or absence of nonpatient comparison group appropriate to study aims)? 90.0% Were the inclusion an...

CONTEXT Given the higher risk of AIDS-defining malignancies that include Kaposi sarcoma (KS), certain non-Hodgkin lymphomas (NHLs), and cervical cancer in persons with human immunodeficiency virus (HIV) infection, the HIV epidemic has likely contributed to the overall numbers of these cancers in the United States. OBJECTIVE To quantify the proportions of KS, AIDS-defining NHLs, and cervical c...

Abstract Inhibitors of Bruton’s tyrosine kinase (BTK) are approved treatments for several B cell lymphomas. However, they characterized by modest selectivity and/or limited central nervous system (CNS) exposure which is important in instances CNS disease. GB5121 an orally available, selective, irreversible, covalent small molecule BTK inhibitor that was designed to address these limitations. He...

BACKGROUND Ollier disease is a rare, nonfamilial disorder that primary affects the long bones and cartilage of joints with multiple enchondromas. It is associated with a higher risk of central nervous system (CNS) malignancies; although the incidence is unknown. CASE DESCRIPTION Here, we present the case of a 55-year-old woman who developed an anaplastic astrocytoma with a known diagnosis of ...

Malignancies of the central nervous system (CNS), particularly glioblastoma and brain metastases from a variety of disease sites, are difficult to treat despite advances in multimodality approaches consisting of surgery, chemotherapy, and radiation therapy (RT). Recent successes of immunotherapeutic strategies including immune checkpoint blockade (ICB) via anti-PD-1 and anti-CTLA-4 antibodies a...

Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal effects predominate. Lung injury is a well described but rare event and has been reported most oft...

CXCR4 belongs to the family of chemokine receptors. Together with its sole known ligand CXCL12 (SDF-1alpha), it has a pivotal role during organogenesis and for homing of hematopoietic stem cells. CXCR4 is overexpressed in various malignancies, and this is often associated with poor prognosis. Therefore, molecular imaging of CXCR4 bears a great potential for diagnostics and selecting patients fo...

BACKGROUND High-dose chemotherapy (HDCT) with autologous stem cell rescue (ASCR) has been reported to be effective in treating children with recurrent central nervous system (CNS) malignancies. METHODS To evaluate the efficacy and toxicities of HDCT and ASCR, the medical records of 27 children with recurrent CNS malignancies who received such therapy at St. Jude Children's Research Hospital b...

SUMMARY BACKGROUND Malignant neoplasms are set to become a leading cause of childhood death in sub-Saharan Africa as immunization programmes reduce deaths due to infectious diseases. Knowledge of the pattern of deaths from these neoplasms is therefore desirable. OBJECTIVE To describe the pattern of deaths from paediatric malignancies, compare this to morbidity figures and provide baseline dat...

OBJECTIVES To describe the patterns of childhood cancers in Hadhramout Sector, Yemen between January 2002 and December 2014.  METHODS This descriptive retrospective study was based on secondary data from Hadhramout Cancer Registry, Hadhramout, Yemen. All Yemeni children under age of 15 years, who were diagnosed with  cancer were included. The International Childhood Cancer Classification syst...