In vitro and in vivo evidence of a decrease in vascular smooth muscle cell (SMC) migration induced by 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors has been reported. When added to SMC cultures for 6 hours, the HMG-CoA reductase inhibitors fluvastatin, simvastatin, and pravastatin at 1 micromol/L resulted in a 48%, 50%, and 16% suppression, respectively, of human coronary...

BACKGROUND In animal models, HMG-CoA reductase inhibitors were able to improve renal function and endothelium-dependent vascular reactivity. In various experimental renal diseases, including autosomal dominant polycystic kidney disease (ADPKD), HMG-CoA reductase inhibitors improved the rate of decline in renal function. We studied the effect of simvastatin on ADPKD patients. METHODS In a doub...

Immune-mediated necrotizing myopathy is a subtype of immune-mediated associated with or without statin use. Statins, HMG-CoA reductase inhibitors, are the most prescribed medications for dyslipidemia. The statin-associated myopathic syndromes range from asymptomatic elevations in creatine kinase to severe debilitating muscle weakness rhabdomyolysis and elevated liver enzymes. Clinical improveme...

Pilot-scale libraries of eight-membered medium ring lactams (MRLs) and related tricyclic compounds (either seven-membered lactams, thiolactams or amines) were screened for their ability to inhibit the catalytic activity of human recombinant 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in vitro. A dozen of the synthetic compounds mimic the inhibition of purified HMG-CoA reductase ac...

Lanosterol is a precursor for cholesterol, which synthesized primarily in the liver pathway often described as mevalonate or HMG-CoA reductase pathway. The first two steps (formation of acetoacetyl CoA and mitochondrial generation (S)-3-hydroxy-3-methylglutaryl-CoA) are also associated with oxidation fatty acids.

background: nephrotic syndrome is a disorder that leads to hyperlipidemia. l-carnitine and genistein can effect on lipid metabolism and the syndrome. in the present study, we have delved into the separate and the twin-effects of l-carnitine and genistein on the gene expressions of hmg-coa reductase and ldl receptor in experimental nephrotic syndrome. methods: in this controlled experimental stu...

Recently, it was reported that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors increased bone mineral density (BMD) in mice. We studied the effect of HMG-CoA reductase inhibitors on BMD of type 2 diabetes mellitus by a retrospective review of medical records. Sixty-nine type 2 diabetic patients were included. The control group (n = 33) did not take HMG-CoA reductase inhibit...