Hypercoagulability increases risk of thrombi that cause cardiovascular events. Here we identify plasma sodium concentration as a factor that modulates blood coagulability by affecting the production of von Willebrand factor (vWF), a key initiator of the clotting cascade. We find that elevation of salt over a range from the lower end of what is normal in blood to the level of severe hypernatremi...

Coagulability varies among men, women, and pregnant women, along a spectrum where the blood of men is the least and that of pregnant women the most coagulable. The effects of differences in coagulation status on the action of heparin cannot be measured by specific laboratory tests such as aPTT or anti-Factor Xa assay. Thromboelastography which measures whole blood coagulation can assess the eff...

Translated from the Second German Edition. New Sydenham Society, 1J01. This is a small work of 336 pages, the first half of which deals with methods of investigation and the chemical and physical properties of the blood, and the latter part with the morphology of the blood and the clinical changes found?in different diseases. The former gives a full and accurate account of the most important me...

A 45-year-old man complained of swelling of the left side of his neck and left upper limb. Ultrasonography and enhanced computed tomography (CT) revealed thrombosis of the left internal jugular, subclavian, and brachiocephalic vein. Based on various examinations, the patient was diagnosed with idiopathic venous thrombosis early in his clinical course. There were no findings to suggest malignanc...

Anticoagulantis an agent that is used to prevent the formation of blood clots. Anticoagulants, such as heparin or warfarin work on chemical reactions in the body to lengthen the time it takes to form a blood clot. Heparin the anticoagulant drug that is used to prevent blood clots from forming during and after surgery and to treat various heart, lung, and circulatory disorders in human body. Hep...

The influence of meals on the coagulability of blood was studied in experiments on 20 men with parallel nonfed controls. The whole blood clotting time in siliconized tubes was not altered by a low-fat meal or by continued absence of a meal, but it was significantly shortened after a meal containing 100 Gm. of butterfat. The degree of lipemia did not determine the degree of shortening. There was...