Reactive hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition related to a cytokine storm leading to multiorgan dysfunction. A better understanding of coagulation disorders, frequently reported in HLH patients, may improve outcomes. Critically ill HLH patients managed in a multidisciplinary national reference center were retrospectively included. Relationships between coagul...

Background: The liver is the cornerstone of the coagulation system. The physiology of blood coagulation is closely linked to liver function as the liver synthesizes most of the factors of the coagulation cascade and fibrinolytic proteins. Objective: The objective of this study was to evaluate coagulation abnormalities associated with chronic liver diseases and determine the coagulation abnormal...

OBJECTIVE To study the clinical characteristic, presentation, complications in patients with congenital coagulation disorders who attended the Congenital Coagulation Disorders Center, Baghdad, Iraq. METHODS This cross-sectional study was conducted in the Center of Congenital Coagulation Disorders, Al-Mansour Pediatric Teaching Hospital, Baghdad, Iraq between March 2008 and August 2008. The sa...

CONTEXT There are contradictory results on the effect of hypothyroidism on the changes in hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). This paper reviews the studies on laboratory and population-based findings regarding hemostatic changes and risk of VTE in hypothyroidism and autoimmune thyroid disorders...

Although many bleeding disorders, such as hemophilia, have been well characterized for many years, the knowledge of hypercoagulability syndromes is significantly less. This is the result of a long-held belief that hypercoagulability disorders were simply related to excessive amounts of the same coagulation factors that patients with bleeding disorders lacked. Now hypercoagulability disorders ar...

Trauma patients have many reasons to have defects in coagulation. These can be caused by the trauma or because of pre-existing disorders. Trauma patients who are at risk for coagulation defects should be screened with the basic tests (aPTT, INR/PT, platelet counts, hematocrit, and fibrinogen), with therapy based on the results. Attention also should be paid to any other correctable factors such...

Among bleeding disorders, hemophilia A, hemophilia B and von Willebrand diseases are the most commonly occurring, whereas deficiencies of other coagulation factors are rare worldwide. Unlike hemophilias, which are X-chromosome linked disorders, the inheritance pattern of the rare coagulation factor deficiencies is generally autosomal recessive. In literature, association of these factor deficie...

www.aafp.org/afp AMERICAN FAMILY PHYSICIAN 419 vessel wall and, in response to the exposed subendothelial collagen, release adenosine diphosphate (ADP) and thromboxane A2. The released ADP and thromboxane A2 cause further platelet aggregation and the formation of a platelet plug that is responsible for primary hemostasis. Secondary hemostatic mechanisms consist of a series of sequential enzymat...

Surgery in patients with congenital or acquired coagulation defects has always been challenging and requires special care with a multidisciplinary approach. Percutaneous nephrolithotomy (PCNL) is a standard procedure performed in patients with kidney stones. Although prone to bleeding more than most of the widely performed surgical procedures, there are not much data regarding PCNL in patients ...

With increasing recognition of the complications related to coagulopathies, it is of paramount importance for all orthopedic surgeons to possess a basic knowledge of common bleeding disorders. The evaluation of the coagulopathic patient requires a careful history, physical examination, and laboratory evaluation. Bleeding disorders commonly include quantitative and qualitative platelet and coagu...