Stuart Prower factor (Factor X) deficiency is a rare hereditary autosomal recessive coagulation disorder. We have come across three cases in the course of last 20 years at our institute. These patients presented with prolonged bleeding after minor trauma, epistaxis, subcutaneous bluish black nodules and two of them presented with history of consanguinity in parents. Hematological findings in co...

Referate – Abstracts – Analyses Physiology and Pathology of Blood Coagulation A Review of the Literature of 1950* (First Part) F. ROLLER, Zurich 1. General aspects. – 2. Prothrombin. – 3. Factor V (ac-globulin, labile factor). – 4. Thromboplastin. – 5. Platelets. – 6. Thrombín, antithrombin. – 7. Fibrinogen, fibrin. – 8. Heparin. – 9. Other anticoagulants. – 10. Thrombosis. -11. Hemophilia. 1. ...

Referate – Abstracts – Analyses Physiology and Pathology of Blood Coagulation A Review of the Literature of 1950* (First Part) F. ROLLER, Zurich 1. General aspects. – 2. Prothrombin. – 3. Factor V (ac-globulin, labile factor). – 4. Thromboplastin. – 5. Platelets. – 6. Thrombín, antithrombin. – 7. Fibrinogen, fibrin. – 8. Heparin. – 9. Other anticoagulants. – 10. Thrombosis. -11. Hemophilia. 1. ...

Referate – Abstracts – Analyses Physiology and Pathology of Blood Coagulation A Review of the Literature of 1950* (First Part) F. ROLLER, Zurich 1. General aspects. – 2. Prothrombin. – 3. Factor V (ac-globulin, labile factor). – 4. Thromboplastin. – 5. Platelets. – 6. Thrombín, antithrombin. – 7. Fibrinogen, fibrin. – 8. Heparin. – 9. Other anticoagulants. – 10. Thrombosis. -11. Hemophilia. 1. ...

Since the initial observation that bleeding is stopped by a platelet plug, it has been clear that platelets play an important role in hemostasis. Patients with very low platelet counts (thrombocytopenia) or with disfunctional platelets have a bleeding diathesis. With the further observation that the platelet plug becomes interwoven with fibrin, it has become clear that platelets interact with t...

Clinical coagulation diagnostics often requires multiple tests. Coagulation times are a first indication of an abnormal coagulation process, such as a coagulation factor deficiency. To determine the specific deficient factor, additional immuno- and/or enzyme assays are necessary. Currently, every clinical laboratory has to normalize their assays (international normalized ratio, INR), and theref...

Thromb Haemost 2006; 95: 920–1 Blood coagulation is founded upon the regulated equilibrium of active and inactive states of trypsin-like proteolytic enzymes. Protein-based cofactors, Ca2+, and a phospholipid surface were woven together with proteolytic enzymes into a response to vascular damage. In addition to these coagulation factors, the most abundant alkali metal in plasma – Na+ – has emerg...

Coagulation factor VIIa (FVIIa) is present at subnanomolar concentration and represents a small percentage of the total amount of FVII in the circulation. FVIIa is poised to initiate blood clotting when it encounters its pivotal cofactor tissue factor (TF) which becomes exposed to blood upon vascular rupture. The requirement for complex formation with TF in order for FVIIa to express procoagula...

OBJECTIVE To provide a comprehensive literature review on roles of coagulation factor XIII (FXIII) in coagulation, wound healing, neoplasm, bone metabolism, and pregnancy. DATA SOURCES All articles in PubMed with key words "Coagulation factor XIII", "wound", "leukemia", "tumor", "bone," and "pregnancy" with published date from 2001 to 2016 were included in the study. Frequently cited publicat...