نتایج جستجو برای: coagulation factor ix

تعداد نتایج: 893342  

2013
Ariella Zivelin

We have evaluated the contribution of depression of individual procoagulant vitamin K-dependent clotting factors to the ability of warfarin to protect rabbits against tissue factor-induced coagulation. Mean activities of individual procoagulant factors were determined, in assays with rabbit substrates, for a group of rabbits achieving a protective degree of anticoagulation with warfarin. Values...

Journal: :Blood 2001
D Gailani D Ho M F Sun Q Cheng P N Walsh

Human coagulation factor XI (FXI) is a plasma serine protease composed of 2 identical 80-kd polypeptides connected by a disulfide bond. This dimeric structure is unique among blood coagulation enzymes. The hypothesis was tested that dimeric conformation is required for normal FXI function by generating a monomeric version of FXI (FXI/PKA4) and comparing it to wild-type FXI in assays requiring f...

2005
Susan T. Lord Dana M. Fowlkes

A DNA polymorphism in the coding region of coagulation factor IX-potentially valuable for carrier detection. pronetel diagnosis. and population studies-was described in 1 985. It had been discovered with monoclonal antibodies that distinguish between threonine and alanine as the 1 48th residue of the peptide. Its use as a diagnostic tool has been limited because threonine-containing factor IX (...

Journal: :Thrombosis and haemostasis 2008
Paul E Monahan

The study of coagulation factors has been rapidly advanced by studies performed in genetically engineered mouse strains. Investigation of factor IX (FIX) has benefited from excellent gene-deleted mouse models that recapitulate many of the features of human haemophilia B. Moreover, advanced positional cloning techniques and availability of technology to allow not only knock-out mice, but also kn...

2010
Monika E Gorczyca Bernd Jilma Christoph Male Sylvia Reitter James C Gilbert Ingrid Pabinger

Background Hemophilia A and B are disorders resulting from a deficiency in factor VIII (FVIII), and factor IX (FIX), respectively. Tissue Factor (TF) is a key component of the extrinsic pathway and plays a role in the coagulation defect of hemophilic blood. Neutralizing the activity of TFPI represents a promising treatment concept in patients with hereditary or acquired hemophilia. ARC19499 is ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1985
A Wallmark R Ljung I M Nilsson L Holmberg U Hedner M Lindvall H O Sjögren

Hemophilia B is an X-chromosomal recessive disease due to deficiency of coagulation factor IX. Three monoclonal antibodies against factor IX were prepared and used to develop immunoradiometric assays (IRMAs) of factor IX antigen (IX-Ag). IX-Ag was measured in 65 normal individuals with one IRMA based on polyclonal anti-IX antibodies and two IRMAs based on three monoclonal anti-IX antibodies. On...

2015
Hui Chen Lei Liu Xingshun Qi Chuangye He Zhanxin Yin Feifei Wu Daiming Fan Guohong Han

BACKGROUND AND AIM The coagulation abnormalities in non-cirrhotic Budd-Chiari syndrome (NC-BCS) and non-cirrhotic portal vein thrombosis (NC-PVT) are unclear. We conducted this case-control study to investigate the coagulation profile of NC-BCS and NC-PVT in Chinese patients. METHODS We measured the levels of factors II, V, VII, VIII, IX, X, XI, XII, protein C (PC), protein S (PS) and antithr...

Journal: :Thrombosis research 2007
Lingfei Xu Manxue Mei Mark E Haskins Timothy C Nichols Patricia O'donnell Karyn Cullen Aaron Dillow Dwight Bellinger Katherine P Ponder

INTRODUCTION Gene therapy could prevent bleeding in hemophilia. However, antibodies could inhibit coagulation, while cytotoxic T lymphocytes could destroy modified cells. The immaturity of the newborn immune system might prevent these immune responses from occurring after neonatal gene therapy. MATERIALS AND METHODS Newborn dogs, cats, or mice were injected intravenously with a retroviral vec...

Journal: :Blood 1983
B Dahlbäck I M Nilsson B Frohm

Lupus anticoagulants are spontaneously occurring antibodies with specificity for negatively charged phospholipids. The plasma of a patient with such a polyclonal antibody of IgM type demonstrated low levels of factor VIII coagulant activity (VIII:C) and factors IX, XI and XII when analyzed by biologic clotting assays, whereas in immunochemical assays, normal levels of VIII coagulant antigen and...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1979
K Katayama L H Ericsson D L Enfield K A Walsh H Neurath E W Davie K Titani

The amino acid sequence of bovine blood coagulation Factor IX (Christmas Factor) is presented and compared with the sequences of other vitamin K-dependent plasma proteins and pancreatic trypsinogen. The 416-residue sequence of Factor IX was determined largely by automated Edman degradation of two large segments, containing 181 and 235 residues, isolated after activating Factor IX with a proteas...

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