BACKGROUND Asthma prevalence varies widely among neighborhoods within New York City. Exposure to mouse and cockroach allergens has been suggested as a cause. OBJECTIVE To test the hypotheses that children living in high asthma prevalence neighborhoods (HAPNs) would have higher concentrations of cockroach and mouse allergens in their homes than children in low asthma prevalence neighborhoods (...

Asthma is a major public health concern. Cockroach allergen exposure and cockroach allergic sensitization could contribute to the higher prevalence of asthma. However, the underlying immune mechanism and the genetic etiology remain unclear. Recent advances have demonstrated that several receptors (PAR-2, TLRs, CLRs) and their pathways mediate antigen uptake from the environment and induce aller...

PURPOSE Cockroach feces are known to be rich in IgE-reactive components. Various protease allergens were identified by proteomic analysis of German cockroach fecal extract in a previous study. In this study, we characterized a novel allergen, a chymotrypsin-like serine protease. METHODS A cDNA sequence homologous to chymotrypsin was obtained by analysis of German cockroach expressed sequence ...

German cockroach extract synergistically regulates tumor necrosis factor-alpha (TNF-alpha)-induced interleukin (IL)-8 expression in human airway epithelial cells. The IL-8 promoter contains nuclear factor (NF)-kappaB, activating protein (AP)-1, and NF for IL-6 (NF-IL6) transcription factor binding regions. Because cockroach extract activates extracellular regulated kinase (ERK), a known activat...

asthma is the most common chronic disease of childhood. exposure to allergens plays an important role in asthma. recently, cockroach has attracted attentions as an important allergen. this study was performed to evaluate cockroach allergy in iranian children with asthma. one hundred children with definite diagnosis of asthma were selected. after obtaining primary information, the severity of th...

Boric acid dust treatments were evaluated as a tool for the integrated management of the German cockroach, Blattella germanica (L.), in commercial confined swine production. The efficacy of boric acid dust was comparable to that of an organic residual insecticide, cyfluthrin, which is commonly used to control cockroaches in this environment. Fall treatments suppressed the cockroach population f...

Effect of static load on activity of motor centers controlling motor activity (walking, flight) was studied in the American cockroach Periplaneta americana L. It has been established that under effect of load on the animal body the relative excitability of these centers increases. A suggestion is put forward about the presence of common neuronal elements in the generator networks providing moto...

The Asian cockroach (Blattella asahinai Mizukubo) was introduced to Florida in 1986 and has since spread throughout the Southeastern United States. Blattella asahinai is a peridomestic pest and high population densities in residential areas can become a nuisance, especially when adults fly into homes. Few studies to date have been conducted on Asian cockroach control, and we evaluated the effic...

Background: Clinically relevant reductions in exposure to cockroach allergen, an important risk factor for asthma in inner-city households, have proven difficult to achieve in intervention trials. Objective: This study investigated a method for the abatement of cockroach allergen in low-income, urban homes. The goal was to reduce mean Bla g 1 concentrations below the previously proposed thresho...