Coenzyme Q10 (CoQ10), first identified by Moor et al in 1940, is a fat soluble quinone with characteristics common to vitamins [1]. It is found in the organs of various animal species with highest concentrations in the heart, liver, kidney, muscles and pancreas [2, 3]. Festenstein et al in 1955 named the substance ubiquinone [2] while Crane et al in 1957 choose the name coenzyme Q [4]. Ubiquino...

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a medical illness characterized by disorders in inflammatory and oxidative and nitrosative (IO&NS) pathways. This paper examines the role of Coenzyme Q10 (CoQ10), a mitochondrial nutrient which acts as an essential cofactor for the production of ATP in mitochondria and which displays significant antioxidant activities. Plasma CoQ10 ...

Mitochondrial impairment and increased oxidative stress are considered to be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease. Coenzyme Q10 (CoQ10) is a component of the electron transport chain localized on the inner membrane of the mitochondria. In addition to its bioenergetic activity required for ATP synthesis, CoQ10 also has antioxidant activity in mi...

Chemical and physical properties. Ubiquinone, chemically is 2,3-dimethoxy-5-methyl-6-polyisoprene parabenzoquinone .It is in its natural form an orange lipophile powder,without odour and taste. Because CoQ10 has 10 isoprenoid units – its name is coenzyme Q10. (2)Molecular weight of CoQ10 is 863.34 g/mol. It is not very stable and deteriorates at temperatures of about 46°C (US Patent 2005). It i...

Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are currently the most effective medications for reducing low-density lipoprotein cholesterol concentrations. Although generally safe, they have been associated with a variety of myopathic complaints. Statins block production of farnesyl pyrophosphate, an intermediate in the synthesis of ubiquinone or coenzyme Q10 (CoQ10). Thi...

We tested the activity of the marine nutraceutical CL-1222 added with a coenzyme Q10 (CoQ10)-lutein-selenium component (Celergen(®), Laboratoires-Dom, Switzerland) to protect human fibroblasts against ultraviolet A (UVA)-induced photoaging. Cells obtained from 22- to 39-year-old healthy donors were pretreated with CL-1222 before UV irradiation, as compared with same quantity of the CoQ10-lutein...

Although it was first described in 1989, our understanding of coenzyme Q10 (CoQ10) deficiency is only now coming of age with the recent first description of the underlying molecular defects. The diverse clinical presentations, classifiable into four major syndromes, raise the question as to whether the deficiencies are primary or secondary. Recent studies, including the one by Mollet, Rötig, an...

The objective of the study aims to evaluate the combined protective effects of coenzyme Q10 and magnesium sulphate on isoproterenol induced myocardial damage in rats. CoenzymeQ10 (50 mg/kg) and magnesium sulphate (10 mg/kg) were administered orally to wistar rats in individual or in combination for 30 days.  At the end of this period, rats were administered isoproterenol (85 mg/kg i.p.) intrape...

Abstract Aim The present study was aimed to clinically evaluate the effectiveness of coenzyme Q10 (CoQ10) in management chronic periodontitis. Materials and Methods A total 60 patients aged between 30 years with bleeding on probing pocket depth (PPD) 3 5 mm were selected divided into three groups, group I receiving scaling root planing, II CoQ10 formulation for 6 weeks, III both planning, follo...

Background: The aim of this study was to evaluate seminal plasma coenzyme Q10 levels and oxidative stress in patients with different types of male infertility. Materials and Methods: The study took place in the Department of Chemistry and Biochemistry, College of Medicine, Al-Nahrain University- Baghdad-Iraq from the period of November 2004 till July 2006. Sixty patients with male infertility w...