نتایج جستجو برای: colistin

تعداد نتایج: 3785  

Journal: :The Southeast Asian journal of tropical medicine and public health 2013
Wanutsanun Tunyapanit Pornpimol Pruekprasert Kamolwish Laoprasopwattana Sureerat Chelae

Multidrug-resistant Pseudomonas aeruginosa (MDR-PA) infection creates problems for therapy. Previous studies have found MDR-PA is susceptible to colistin. We studied the in vitro susceptibility of MDR-PA to colistin and determined the minimum inhibitory concentration (MIC). One hundred MDR-PA isolates were obtained from patients at Songklanagarind Hospital, in southern Thailand, during January ...

2017
Shahriar Sepahvand Mohammad Ali Davarpanah Amir Roudgari Abbas Bahador Vajihe Karbasizade Zahra Kargar Jahromi

Background Acinetobacter baumannii is an important human pathogen which has recently gained increased attention due to the occurrence of drug-resistant nosocomial infections in patients suffering from immune system disorders, and those in hospital intensive care units. The aim of this research was to identify and isolate A. baumannii strains resistant to colistin, determine antibiotic resistanc...

Journal: :Macromolecular bioscience 2017
Chongyu Zhu Jinxin Zhao Kristian Kempe Paul Wilson Jiping Wang Tony Velkov Jian Li Thomas P Davis Michael R Whittaker David M Haddleton

There is an urgent unmet medical need for new treatments for wound and burn infections caused by multidrug-resistant Gram-negative "superbugs," especially the problematic Pseudomonas aeruginosa. In this work, the incorporation of colistin, a potent lipopeptide into a self-healable hydrogel (via dynamic imine bond formation) following the chemical reaction between the amine groups present in gly...

2014
Duygu Percin Selcan Akyol Gamze Kalin

AIM The in vitro activity of colistin in combination with sulbactam, netilmicin, and vancomycin against colistin-resistant A. baumannii strains was investigated. Furthermore, the clonal relationship of the strains was analyzed. METHODS Clonal relationship was investigated using rep-PCR. To screen for synergysm, the fractional inhibitory concentration index (FICI) was calculated using checkerb...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2013
Emanuele Durante-Mangoni Giuseppe Signoriello Roberto Andini Annunziata Mattei Maria De Cristoforo Patrizia Murino Matteo Bassetti Paolo Malacarne Nicola Petrosillo Nicola Galdieri Paola Mocavero Antonio Corcione Claudio Viscoli Raffaele Zarrilli Ciro Gallo Riccardo Utili

BACKGROUND Extensively drug-resistant (XDR) Acinetobacter baumannii may cause serious infections in critically ill patients. Colistin often remains the only therapeutic option. Addition of rifampicin to colistin may be synergistic in vitro. In this study, we assessed whether the combination of colistin and rifampicin reduced the mortality of XDR A. baumannii infections compared to colistin alon...

2013
Michael T. Eadon Bradley K. Hack Jessy J. Alexander Chang Xu M. Eileen Dolan Patrick N. Cunningham

Eadon MT, Hack BK, Alexander JJ, Xu C, Dolan ME, Cunningham PN. Cell cycle arrest in a model of colistin nephrotoxicity. Physiol Genomics 45: 877–888, 2013. First published August 6, 2013; doi:10.1152/physiolgenomics.00076.2013.—Colistin (polymixin E) is an antibiotic prescribed with resurging frequency for multidrug resistant gram negative bacterial infections. It is associated with nephrotoxi...

Journal: :The Journal of antimicrobial chemotherapy 2009
Nobumasa Aoki Kazuhiro Tateda Yoshiaki Kikuchi Soichiro Kimura Choichiroh Miyazaki Yoshikazu Ishii Yoshinari Tanabe Fumitake Gejyo Keizo Yamaguchi

OBJECTIVES Multidrug-resistant Pseudomonas aeruginosa (MDRP) is becoming a serious problem in hospitals, especially in patients on ventilators. Recent data demonstrate that colistin may be effective for these patients, although limited in vitro and in vivo data are available. Our aim was to identify further characteristics of colistin for the therapy of pneumonia caused by MDRP. METHODS The e...

Journal: :Antimicrobial agents and chemotherapy 2008
Joshua S Hawley Clinton K Murray James H Jorgensen

Colistin heteroresistance has been reported among Acinetobacter isolates; however, its association with prior colistin therapy has not been not described. A population analysis profile identified resistant Acinetobacter subpopulations from colistin-susceptible clinical isolates. The proportion of cells exhibiting heteroresistance was significantly higher among isolates recovered from patients t...

Journal: :The Journal of antimicrobial chemotherapy 2011
Béatrice Berçot Laurent Poirel Laurent Dortet Patrice Nordmann

OBJECTIVES To analyse the in vitro activity of colistin, fosfomycin and tigecycline alone or in combination against enterobacterial NDM-1 producers. METHODS MIC values of colistin, fosfomycin and tigecycline were determined for 28 NDM-1-producing enterobacterial isolates. In vitro synergy combination testing was performed for eight clinical isolates and one Escherichia coli transconjugant (si...

2017
Eulalia Sans-Serramitjana Marta Jorba José Luis Pedraz Teresa Vinuesa Miguel Viñas

The emergence of colistin-resistant Pseudomonas aeruginosa in cystic fibrosis (CF) patients, particularly after long-term inhalation treatments, has been recently reported. Nanoen-capsulation may enable preparations to overcome the limitations of conventional pharmaceutical forms. We have determined the time-dependent viability of P. aeruginosa biofilms treated with both free and nanoencapsulat...

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