Abstract Introduction Current treatments for obstructive sleep apnoea (OSA) typically target the anatomical pathophysiological endotype and are either not tolerated or effective in a significant proportion of patients. Pharmaceuticals may provide an alternative therapeutic option address some all remaining endotypes (loop gain, muscle compensation arousal threshold). This randomised, double-bli...

We characterized the passive structural and active neuromuscular control of pharyngeal collapsibility in mice and hypothesized that pharyngeal collapsibility, which is elevated by anatomic loads, is reduced by active neuromuscular responses to airflow obstruction. To address this hypothesis, we examined the dynamic control of upper airway function in the isolated upper airway of anesthetized C5...

Early stage acute kidney injury (AKI) is an independent risk factor for an increase in mortality. Accurate assessment of volume status is a major challenge during the early stages of acute renal injury. Determining volume status based on the history and physical exam lacks accuracy. Urine sodium and free excretion of sodium (FENa) provide objective evidence of intravascular volume status when i...

We prove a sufficient condition for finite clique complex to collapse k-dimensional complex, and use this exhibit thresholds (k+1)-collapsibility in sparse random complex. In particular, if every strongly connected, pure (k+1)-dimensional subcomplex of X has vertex degree at most 2k+1, then is (k+1)-collapsible. the model X(n,p) complexes an Erdős–Rényi graph G(n,p), we show that any fixed k≥0,...

The relationship between changes in absolute end-expiratory lung volume (EELV) and collapsibility has not been rigorously quantified. We hypothesized that pharyngeal collapsibility varies inversely with absolute lung volume in sleeping humans during 1) conventional and 2) isovolume measurements of passive critical pressure (Pcrit). Eighteen healthy subjects (11 male, 7 female) slept in a negati...