نتایج جستجو برای: colonic delivery
تعداد نتایج: 231455 فیلتر نتایج به سال:
OBJECTIVE The colonic microbiota ferment dietary fibres, producing short chain fatty acids. Recent evidence suggests that the short chain fatty acid propionate may play an important role in appetite regulation. We hypothesised that colonic delivery of propionate would increase peptide YY (PYY) and glucagon like peptide-1 (GLP-1) secretion in humans, and reduce energy intake and weight gain in o...
After the dosing of an extended-release (ER) formulation, compounds may exist in solutions at various concentrations in the colon because the drugs are released at various speeds from the ER dosage form. The aim of this study was to investigate the relationship between the drug concentration profiles in plasma and the drug doses in the colon. Several drug solutions of different concentrations w...
colonic lipoma is a benign neoplasm that can lead to colonic obstruction but concomitant intussusception is rare in adults. in this case, colocolic intussusception due to a lipoma in the descending colon had occurred. by laparatomy, we diagnosed the problem , but reduction was impossible . so resection of the colon with mass was done and anastomosed. after surgery and 3 years follow up the pati...
BACKGROUND Different methods have been studied for targeting drugs to the colon, such as pH-based, time dependent and bacterially degradable systems. However, due to variations in physiological conditions of patients, one system alone could not be completely reliable on colonic drug delivery. OBJECTIVES The aim of this study was preparation and evaluation of a novel colon-specific drug delive...
We have previously shown that lambs delivered by caesarean section 1 week prematurely become hypothermic due to reduced brown adipose tissue function in conjunction with low plasma concentrations of cortisol and thyroid hormones. The present study therefore aimed to determine whether maternal dexamethasone (a synthetic corticosteroid) administration could improve thermoregulation in premature l...
Characterization Formulation and in Vitro Assesment of Pulsatile Drug Delivery of Montelukast Sodium
The Montelukast pulsatile delivery system was created with the goal of delivering drug to colon for successful treatment nocturnal asthma. microspheres were sealed within insoluble hard gelatin capsule body an erodible hydrogel plug create a time delayed capsule. Emulsion solvent evaporation used make microspheres. Based on dissolving tests, optimised microsphere formulations designed. entire d...
Clinical trials were carried out in order to determine the value of metronidazole in preventing the development of anaerobic infections after surgery. Following a successful controlled trial of hysterectomy patients, among whom the prophylactic use of oral metronidazole resulted in a reduction of the anaerobic sepsis rate from 25% to nil, further trials were carried out with patients having urg...
Prostaglandin E₂ receptor subtype 4 (EP4) agonists are known to reduce intestinal inflammation and enhance epithelium regeneration. We explored the possibility of colonic delivery of an EP4 agonist, 2-[(4-{[2-((1R,2R,3R)-3-hydroxy-2-{(1E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl}-5-oxocyclopentyl)ethyl]sulfanyl}butanoyl)oxy]ethyl nonanoate (ONO-AE2-724), using poly(lactic-coglycolic a...
Abstract Colonic crypts are tubular glands that multiply through a symmetric branching process called crypt fission. During the early stages of colorectal cancer, normal fission is disturbed, leading to asymmetrical or budding. The challenging shapes budding make it difficult prepare paraffin sections for conventional histology, resulting in colonic cross with only partially visible. To study s...
case presentation we report a case of idiopathic colonic varices, diagnosed at a routine colonoscopy performed for nespecific abdominal disturbances in a female patient without liver disease or pancreatic conditions responsible for portal hypertension development. conclusions the development of colonic varices in the absence of a certain trigger represents a major issue for practitioners due to...
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