Protease responsive nanosensors were obtained by the attachment of unique green fluorescent bifunctional 3-arylcoumarin-derived fluorogenic substrates to poly(acrylamide-co-N-(3-aminopropyl)methacrylamide) nanoparticles, in which proteolysis results in substantial signal amplification.

SEVERE W0U2TD OF THE HEAD BY A BEAR. Reported by V. Richards, Esq., Civil Surgeon of Bancaorah. Bolai Dey, a Ilindoo, aged 22 years, was admitted into the Bancoorah Charitable Dispensary, on the 30th of December, 1870. The elder brother, who accompanied the patient, stated that while they were cutting wood in the jungle, a bear rushed out and attacked Bolai, inflicting severe wounds. He (the el...

Dynamic co-operativity in monomeric enzymes is characterized in terms of a non-Michaelis-Menten kinetic behaviour. The latter is believed to be associated with mechanisms that include multiple reaction pathways due to enzymatic conformational fluctuations. Recent advances in single-molecule fluorescence spectroscopy have provided new fundamental insights on the possible mechanisms underlying re...

A 'co-templating' strategy supported by molecular modelling has been used to prepare, for the first time, silicoaluminophosphates with the SAV and KFI framework topologies, each of which has a three-dimensionally connected pore system with high specific volume.

Firms faced with the decision of whether to standardize or not prior to introducing a new network technology face a tradeoff: Compatibility improves the technology’s chances of consumer acceptance, but it also means having to share the resulting profits with other sponsors of the standard. In this paper, we show that even prior to market introduction of a new technology, the timing of decisions...

Fifty-nine male patients and 41 female patients with uncomplicated gonorrhoea were treated with an intramuscular dose of 1600 mg sulphamethoxazole plus 320 mg trimethoprim followed by an oral dose of 2400 mg sulphamethoxazole plus 480 mg trimethoprim 12 hours later. Forty-nine out of 52 male patients and 37 out of 38 female patients who were re-examined were cured. One of the men probably had a...