Septic cavernous sinus thrombosis is a rare clinical condition. Although Staphylococcus aureus is the most common pathogen causing septic cavernous sinus thrombosis [CST], it is an uncommon cause of meningitis. We report the first case of CST with meningitis in Hyderabad, Andhra Pradesh, caused by community acquired epidemic strain of Methicillin resistant staphylococcus aureus [MRSA], in a pre...

Staphylococcus aureus is an ubiquitous bacterium that is frequently part of the human microflora, causing disease when the immune system becomes compromized. Although S. aureus can be found in different parts of the body, anterior nares are the main ecological reservoir in humans [1]. This versatile pathogen is responsible for a wide variety of diseases, including superficial, systemic and life...

To the Editor: In the past 30 years, methicillin-resistant Staphylococcus aureus (MRSA) has been the leading cause of nosocomial infections throughout the world. Healthcare-associated MRSA (HA-MRSA) isolates are resistant to multiple antimicrobial drugs. This resistance severely hampers treatment options. During the past decade, MRSA isolates have also emerged as major pathogens in the communit...

The worldwide emergence of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) can have severe public health implications. Familial transmissions of CA-MRSA in The Netherlands were investigated. Among the families studied, two clusters of CA-MRSA could be identified. This report demonstrates that family members can serve as reservoirs of CA-MRSA which may become a serious p...

BACKGROUND Methicillin-resistant Staphylococcus aureus (MRSA) isolates are increasingly frequent causes of skin and soft-tissue infections or invasive infections in many communities. METHODS Prospective surveillance for community-acquired S. aureus infections at Texas Children's Hospital was initiated on 1 August 2001. Infections meeting the definition of community-acquired were identified. D...

OBJECTIVE To describe antimicrobial resistance and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) isolated in community settings in Australia. DESIGN AND SETTING Survey of S. aureus isolates collected prospectively Australia-wide between July 2004 and February 2005; results were compared with those of similar surveys conducted in 2000 and 2002. MAIN OUTCOME MEA...

Methicillin-resistant Staphylococcus aureus is an established nosocomial pathogen (HA-MRSA, hospital acquired MRSA), but has recently begun to appear in the community (CA-MRSA, community acquired MRSA). The cause of resistance to methicillin and all other beta-lactam antibiotics is the mecA gene, which is situated on a mobile genetic element, the Staphylococcal Cassette Chromosome mec (SCCmec)....

Mechanisms underlying the enhanced virulence phenotype of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are incompletely defined, but presumably include evasion of killing by human polymorphonuclear leukocytes (PMNs or neutrophils). To better understand this phenomenon, we investigated the basis of rapid PMN lysis after phagocytosis of USA300, a prominent CA-MRSA st...

OBJECTIVES To compare the demographics, antimicrobial susceptibilities and molecular epidemiology of community-associated (CA) and healthcare-associated (HA) methicillin-resistant Staphylococcus aureus (MRSA) in Canada. METHODS Between 2007 and 2011, 1266 MRSA were collected from inpatients and outpatients attending tertiary-care medical centres across Canada. Susceptibility testing was perfo...

Among 10 strains of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) isolated in 2002 from patients with skin infections, seven harbored the Panton-Valentine leukocidin gene, two harbored the exfoliative toxin A gene, and one harbored neither of these genes. CA-MRSA isolates producing a variety of exotoxins are currently spreading in the Swiss community.