This consensus document reviews the evidence on the evaluation of biological drugs. The main conclusions of the group are: a) the current evidence on biological comparisons is based on indirect comparisons and is generally unreliable and with important methodological limitations. Therefore, b) it is considered necessary to amend the regulatory directives in the sense of strongly favoring random...

BC3 logo BC version 3 and 4. By default, Beyond Compare 3 and 4 support a read-only comparison of Word, Excel, and PDF files.Or, thoroughly verify every file with byte-by-byte comparisons. The text contents of Microsoft Word.doc and Adobe.pdf files can also be compared but not.Do you know a good Windows software to compare PDF files side-by-side and show. If you are comparing text inside a pdf,...

A common high level task for the user of complex modelling software is making comparisons between models. The differences between the current and previous models guide future modelling efforts and model acceptance. This paper explores an interactive graphical paradigm to support this task. The computer displays the state history—the series of states the system takes one—corresponds closely to a...