Capecitabine is an oral chemotherapeutic agent converted to 5 fluorouracil (5-FU). Neurotoxicity associated with the medication encompasses both central and peripheral nervous systems. We describe a 60 year old man with colonic carcinoma who developed diplopia due to a sixth nerve palsy following the use of capecitabine which is an orally administered prodrug of 5-FU. An MRI of brain did not re...

A 45-year-old woman reported multiple episodes of reversible left eye pain and diplopia stretching over 12 years. Ophthalmic examinations had repeatedly disclosed a left sixth cranial nerve palsy. Postcontrast brain MRI performed 3 weeks after clinical onset of the most recent episode demonstrated enhancement of the cisternal segment of the left sixth cranial nerve. Five months later, when symp...

Leptospirosis, a disease of great significance in tropical countries, presents commonly as a biphasic illness with acute febrile episode in the first phase followed by a brief afebrile period and then by the second phase of fever with or without jaundice and renal failure. However, it has varied manifestations and unusual clinical features ascribed to immunological phenomena can occur due to th...

We reported two cases of the central nervous system (CNS) multiple myeloma (MM) with unusual presentation sixth nerve palsy. The first patient developed in setting newly diagnosed MM and second relapsed refractory setting. One underwent surgery, other received radiation. Both patients systemic chemotherapy noted improvement. also performed a comprehensive literature review previously published ...

one of the important causes of strabismus in all ages is extraocular muscles paralysis due to 3rd, 4th and 6th cerebral nerve palsies. exact and on-time treatment can result in improvement of deviation, am-blyopia and abnormal head posture. we studied epidemiological characteristics of extraocular muscles paralysis. this retrospective study performed on 131 subjects (58% male). records of patie...

A 15-year-old girl who presented with a bilateral sixth nerve palsy caused by infectious mononucleosis is described. The neurological presentation of infectious mononucleosis is discussed.

Acute abducens palsy of para-infectious origin is uncommon in adulthood. We present the case history of a 28-year-old woman suffering from acute onset diplopia due to abducens palsy. Magnetic resonance imaging revealed signs suggestive of frank ipsilateral maxillary sinusitis. The lack of anatomical relationship between the maxillary sinus and the abducens nerve led us to conclude that the abdu...

Purpose: To investigate the causes of isolated ocular motor nerve palsy in patients with a history cancer.Methods: The charts 30 cancer diagnosed acquired third, fourth, and sixth cranial palsies from March 2013 to December 2021 were retrospectively reviewed. Sex, age onset, underlying disease analyzed.Results: Sixth (n = 18, 60.0%) was most common. Brain metastasis 13, 43.3%) common etiology, ...

Isolated abducens nerve paresis related to ruptured vertebral artery (VA) aneurysm is rare. It usually occurs bilaterally or ipsilaterally to the pathologic lesions. We report the case of a contralateral sixth nerve palsy following ruptured dissecting VA aneurysm. A 38-year-old man was admitted for the evaluation of a 6-day history of headache. Abnormalities were not seen on initial computed to...