OBJECTIVE this paper reports an association between an increased Nuchal Translucency (NT) and Osteogenesis Imperfecta (OI), a type of skeletal dysplasia. Measurement of fetal NT at 10-14 weeks of gestation is a sensitive and effective screening method for chromosomal abnormalities. METHODS a 35-year- old Caucasian woman in her fourth pregnancy was referred to our clinic for an ultrasound scan...

INTRODUCTION Zoledronic acid or zo/edronate is a potent bisphosphonate that recently has been used in children with osteoporosis and osteogenesis imperfecta (01), so it could be an option in the treatment of children with this terrible disease that virtually condemns them to a life of pain and prostration. The aim of this study was to evaluate the clinical and biochemical conditions of pediatri...

Abstract Background The repair of large bone defects is a great challenge for orthopedics. Although the development three-dimensional (3D) printed titanium alloy (Ti6Al4V) implants with optimized pore structure have effectively promoted osseointegration. However, due to biological inertia Ti6Al4Vsurface and neglect angiogenesis, some patients still suffer from postoperative complications such a...

Background: Craniofacial anomalies present a challenge to all health care practitioners since they necessitate long-term team follow-up, which is difficult achieve outside of major center where craniofacial teams normally collaborate. Objectives: The current review with an illustrative case focuses on the representation and Crouzon syndrome its maxillofacial implications. Review different varie...

limb lengthening by distraction osteogenesis was fi   fi key words: biomechanics, callostasis, distraction histogenesis, distraction osteogenesis,mechanical strain, osteodistraction, vector   ed the physiologic and mechanical factors governing   successful regeneration of bone formation. distraction osteogenesis is a new variation of more traditional orthognathic surgical procedure for the corr...

Osteogenesis imperfecta (OI), a congenital bone disorder, is caused by mutations in COL1A1 and COL1A2 genes, leading to deficiency of type I collagen. The high resolution melting (HRM) analysis has been used for detecting mutations, polymorphisms and epigenetic alteration in double-stranded DNAs. This study was to evaluate the potential application of HRM analysis for identifying gene mutations...

Five cases are presented to exemplify technical difficulties and complications which may be encountered when performing distraction osteogenesis in the facial skeleton. The procedure should be performed under close supervision by the surgical and orthodontic colleagues. Errors in the choice of vector may be managed by earlier removal of the distractor and subsequent traction on the previously o...

OBJECTIVE Osteogenesis imperfecta (OI) is a rare connective tissue and bone disease that results in a bone fragility of varying severity. The objective was to determine and describe the OI in the Valencia Region (VR) during the period 2004 to 2014. METHODS From the Rare Diseases Information System of the VR (SIER-CV) patients from 2004 to 2014 with the codes of the International Classificatio...

Mesenchymal stem cells are stem/progenitor cells originated from the mesoderm and can different into multiple cell types of the musculoskeletal system. The vast differentiation potential and the relative ease for culture expansion have established mesenchymal stem cells as the building blocks in cell therapy and tissue engineering applications for a variety of musculoskeletal diseases, includin...

Varying degrees of upper airway obstruction is almost universally present in patients of congenital micrognathia which needs to be corrected as early as possible. This allows appropriate feeding and growth and prevents long-term complications such as pulmonary hypertension and cor pulmonale. We report the case of a tracheostomy-dependent, 4-year-old child with congenital micrognathia who was tr...