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All intracellular proteins undergo continuous synthesis and degradation. Chaperone-mediated autophagy (CMA) is necessary to maintain cellular homeostasis through turnover of cytosolic proteins (substrate proteins). This degradation involves a series of substrate proteins including both cancer promoters and suppressors. Since activating or inhibiting CMA pathway to treat cancer is still debated,...

A variable step-size control by error power was proposed to improve the performance of adaptive constant modulus blind equalization algorithm based on the analysis of the cost function. In the Constant Modulus Algorithm (CMA), large step-size can achieve faster convergence rate, but the steady-state residual error is big, on the contrary, small step-size can achieve higher convergence precision...

In recent years, meta-analysis studies have become a popular field of study in order to quantitatively analyze the results obtained from more than one carried out independently same subject and interpret holistic perspective. Because this, different licensed open source software has been developed last 20 years. With this study, it is aimed compare existing programs terms quantitative qualitati...

Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble proteins in lysosomes. CMA contributes to cellular quality control and is activated as part of the cellular response to different stressors. Defective CMA has been identified in ageing and different age-related diseases. Until now, CMA activity could only be measured in vitro using isolated lysosomes. Her...

Chaperone-mediated autophagy (CMA) is activated in response to cellular stressors to prevent cellular proteotoxicity through selective degradation of altered proteins in lysosomes. Reduced CMA activity contributes to the decrease in proteome quality in disease and ageing. Here, we report that CMA is also upregulated in response to genotoxic insults and that declined CMA functionality leads to r...

Cross Tensor Approximation (CTA) is a generalization of Cross/skeleton matrix and CUR Matrix (CMA) suitable tool for fast low-rank tensor approximation. It facilitates interpreting the underlying data tensors decomposing/compressing in such way that their structures as nonnegativity, smoothness, or sparsity can be potentially preserved. In this paper, we review extend state-of-the-art determini...

The covariance matrix adaptation evolution strategy (CMA-ES) is one of the most powerful evolutionary algorithms for real-valued single-objective optimization. In this paper, we develop a variant of the CMA-ES for multi-objective optimization (MOO). We first introduce a single-objective, elitist CMA-ES using plus-selection and step size control based on a success rule. This algorithm is compare...

Chaperone-mediated autophagy (CMA) represents a selective form of autophagy involved in the degradation of specific soluble proteins containing a pentapeptide motif that is recognized by a cytosolic chaperone able to deliver proteins to the lysosomes for degradation. Physiologically, CMA contributes to maintain crucial cellular functions including energetic balance and protein quality control. ...