Background: This study investigated the experience of 23 incarcerated male adolescents who participated in an adapted 10-week mindfulness-based intervention. Method: Participants completed semi-structured interviews immediately following the final class of the treatment intervention. A six-step thematic content analysis was used to identify major themes from the transcribed semi-structured inte...

Mindfulness-based curricular interventions can support adolescents who are at risk of school failure as they negotiate the transition from high school into young adulthood. Researchers hypothesized that a 6-week mindfulness-based intervention would lower participants' perceived stress while increasing their reported levels of self-esteem. Participants (N = 23) ranged in age from 17 to 20 years ...

N-Acetyl-S-farnesyl cysteine (AFC) is the minimal synthetic substrate for the enzyme Icmt, which methylates prenylated proteins. The desthio-AFC isostere 2 has been synthesized in racemic form. This analog was not an Icmt substrate, but instead a weak inhibitor with an IC50 of approximately 325 microM.

Several studies (2-6) of the hydrolysis of proteins by proteolytic eneymes have led to the suggestion that only denatured forms of the substrate are acted on; and that where an equilibrium between native (N) and denatured (D) forms, N $ D, is not spontaneous, the initial action of a protease may be a nonhydrolytic denaturation of native substrate. Green and Neurath (7) have suggested that nativ...

1. A quantitative method for the determination of pepsin is described depending on the change in conductivity of a digesting egg albumin solution. 2. The combination of pepsin with an insoluble substrate has been followed by this method. 3. The amount of pepsin removed from solution by a given weight of substrate is independent of the size of the particles of the substrate. 4. There is an optim...

1. Evidence is presented that pepsin is a univalent acid with a value for pK of 6.85 (or a base, with pK 7.39). 2. The autodestruction of the pepsin is shown to be dependent in part upon an instantaneous irreversible change occurring in the ionized form of the enzyme (if it be an acid) or in the unionized form (if it be a base). 3. A further progressive autodestruction of pepsin at any given hy...

Purpose Our research of MBSR for mostly female urban youth showed reductions in conflict, anxiety, and stress, as well as increased self-regulation. Reviews of mindfulness instruction suggest benefit but call for increased methodological rigor, particularly active control conditions. Here, we explore the specific effects of MBSR compared with an active control on stress and coping among young u...

In two previous communications the authors have described a synthesis of protein by pepsin in a concentrated peptic hydrolysate of albumin (1) ; and the effect of temperature on this synthesir (2). The justification for describing the synthetic product as protein is discussed in our previous paper (2). In these communications the optimum hydrogen ion concentration was stated to be pH 4.0; but t...

Effects of seven cytochalasans including cytochalasins B, D and E and novel phenochalasins A and B were tested on cytosolic lipid droplet formation and neutral lipid synthesis in mouse peritoneal macrophages. Phenochalasin A inhibited lipid droplet formation in a dose-dependent manner at least up to 20 microM without any morphological changes in macrophages. Cytochalasins D and E also inhibited...

We report here results of a worldwide survey of apolipoprotein (apo) A1 and B measurements. A lyophilized pool of human serum was developed for the survey to test its suitability as a candidate Reference Material. Seventy-five laboratories from 18 countries responded to invitations to participate. Using several methods, they evaluated the mass concentration of apo A1 and B in the proposed Refer...